Document Detail

Augmented chemoreceptor reflex tonic drive in early human hypertension and in normotensive subjects with family background of hypertension.
MedLine Citation:
PMID:  3834754     Owner:  NLM     Status:  MEDLINE    
The study was carried out in 30 subjects with mild primary hypertension and in 82 normotensive age-matched volunteers, 18-20 years of age. Hyperoxia test was used to withdraw the tonic chemoreceptor reflex drive. The following circulatory and respiratory effects of short lasting hyperoxia were observed in the hypertensive group and in most of the normotensive subjects yet with a family background of hypertension: a decrease in the mean arterial pressure, in total peripheral vascular resistance, and in forearm vascular resistance, and a significantly greater reduction of the resting ventilation as compared to the normotensive group. Our results suggest that the augmented arterial chemoreceptor drive is one of the mechanisms responsible for the elevated arterial blood pressure and total peripheral resistance in early human hypertension. The positive response to hyperoxia test in healthy subjects with a family background of hypertension suggests a familial occurrence of the hyperactivity of the arterial chemoreceptors.
M Tafil-Klawe; A Trzebski; J Klawe; T Pałko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta physiologica Polonica     Volume:  36     ISSN:  0044-6033     ISO Abbreviation:  Acta Physiol Pol     Publication Date:    1985 Jan-Feb
Date Detail:
Created Date:  1986-06-06     Completed Date:  1986-06-06     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985166R     Medline TA:  Acta Physiol Pol     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  51-8     Citation Subset:  IM    
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MeSH Terms
Blood Circulation / drug effects
Blood Pressure
Chemoreceptor Cells / physiopathology*
Forearm / blood supply
Hypertension / genetics,  physiopathology*
Oxygen / pharmacology
Reference Values
Reflex / physiology*
Respiration / drug effects
Vascular Resistance
Reg. No./Substance:

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