Document Detail


Augmented bioavailability and cysticidal activity of albendazole reformulated in soybean emulsion in mice infected with Echinococcus granulosus or Echinococcus multilocularis.
MedLine Citation:
PMID:  11904106     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The anthelminthic drug, albendazole (Abz), was reformulated in a soybean oil emulsion and evaluated as a therapeutic agent for the treatment of Echinococcus granulosus and Echinococcus multilocularis in mice. Abz emulsified with 30% soybean oil (AbzE-30) resulted in higher circulating plasma concentrations of the major bioactive Abz metabolite, Abz sulfoxide (AbzSOX), after oral administration, compared with an Abz suspension. The soybean oil-emulsified Abz compound was also noted to penetrate into the hydatid cyst wall and produced higher hydatid cyst concentrations of AbzSOX. The emulsion was superior to Abz suspension in reducing the size of hydatid cysts caused by E. granulosus protoscolices collected from naturally infected sheep in Urumchi, Xinjiang Uygar Autonomous Region. In contrast, the reformulated compound's ability to reduce E. multilocularis cyst masses was only marginally superior to Abz suspension. AbzE-30 exhibited increased bioavailability and bioactivity in the treatment of murine Echinococcus hydatid cyst infections. The compound has the potential for improving therapeutic outcomes for human echinococcosis.
Authors:
Xiao Shuhua; You Jiqing; Wang Mingjie; Jiao Pieying; Gao Fanghua; Chai Junjie; Jiao Wei; Peter Hotez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta tropica     Volume:  82     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-20     Completed Date:  2002-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  77-84     Citation Subset:  IM    
Affiliation:
Institute of Parasitic Diseases, Chinese Academy of Preventive Medicine, 207 Rui Jin Er Lu, 200025, Shanghai, PR China. shxiao1@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Albendazole / administration & dosage,  pharmacokinetics*,  therapeutic use*
Animals
Anthelmintics / administration & dosage,  pharmacokinetics*,  therapeutic use*
Biological Availability
Echinococcosis / drug therapy*
Emulsions
Female
Male
Mice
Models, Animal
Soybean Oil
Chemical
Reg. No./Substance:
0/Anthelmintics; 0/Emulsions; 54965-21-8/Albendazole; 8001-22-7/Soybean Oil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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