| Augmented ST-segment elevation during recovery from exercise predicts cardiac events in patients with Brugada syndrome. | |
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MedLine Citation:
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PMID: 21029874 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The goal of this study was to evaluate the prevalence and the clinical significance of ST-segment elevation during recovery from exercise testing. BACKGROUND: During recovery from exercise testing, ST-segment elevation is reported in some patients with Brugada syndrome (BrS). METHODS: Treadmill exercise testing was conducted for 93 patients (91 men), 46 ± 14 years of age, with BrS (22 documented ventricular fibrillation, 35 syncope alone, and 36 asymptomatic); and for 102 healthy control subjects (97 men), 46 ± 17 years of age. Patients were routinely followed up. The clinical end point was defined as the occurrence of sudden cardiac death, ventricular fibrillation, or sustained ventricular tachyarrhythmia. RESULTS: Augmentation of ST-segment elevation ≥0.05 mV in V(1) to V(3) leads compared with baseline was observed at early recovery (1 to 4 min at recovery) in 34 BrS patients (37% [group 1]), but was not observed in the remaining 59 BrS patients (63% [group 2]) or in the 102 control subjects. During 76 ± 38 months of follow-up, ventricular fibrillation occurred more frequently in group 1 (15 of 34, 44%) than in group 2 (10 of 59, 17%; p = 0.004). Multivariate Cox regression analysis showed that in addition to previous episodes of ventricular fibrillation (p = 0.005), augmentation of ST-segment elevation at early recovery was a significant and independent predictor for cardiac events (p = 0.007), especially among patients with history of syncope alone (6 of 12 [50%] in group 1 vs. 3 of 23 [13%] in group 2) and among asymptomatic patients (3 of 15 [20%] in group 1 vs. 0 of 21 [0%] in group 2). CONCLUSIONS: Augmentation of ST-segment elevation during recovery from exercise testing was specific in patients with BrS, and can be a predictor of poor prognosis, especially for patients with syncope alone and for asymptomatic patients. |
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Authors:
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Hisaki Makimoto; Eiichiro Nakagawa; Hiroshi Takaki; Yuko Yamada; Hideo Okamura; Takashi Noda; Kazuhiro Satomi; Kazuhiro Suyama; Naohiko Aihara; Takashi Kurita; Shiro Kamakura; Wataru Shimizu |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 56 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-29 Completed Date: 2010-11-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1576-84 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Arrhythmia and Electrophysiology, Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Osaka, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brugada Syndrome / complications, mortality, physiopathology* Death, Sudden, Cardiac* / etiology Exercise Test / methods* Female Follow-Up Studies Humans Male Middle Aged Predictive Value of Tests Tachycardia, Ventricular / etiology, mortality, physiopathology* Ventricular Fibrillation / etiology, mortality, physiopathology* |
| Comments/Corrections | |
Comment In:
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J Am Coll Cardiol. 2010 Nov 2;56(19):1585-8
[PMID:
21029875
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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