Document Detail


Augmentation pressure and subendocardial viability ratio are associated with microalbuminuria and with poor renal function in type 1 diabetes.
MedLine Citation:
PMID:  20605853     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this report we explore the hypothesis that arterial stiffness indices, which predict cardiovascular disease, might also correlate with microalbuminuria (MA) in type 1 diabetes (T1D), and thus have potential for risk assessment. Three pulse wave analysis (PWA) indices, measured using the SphygmoCor device, were evaluated on 144 participants with childhood-onset T1D. These variables, augmentation index (AIx), augmentation pressure (AP) and subendocardial viability ratio (SEVR, an estimate of myocardial perfusion) (an estimate of myocardial perfusion), were each analysed cross-sectionally in relation to both prevalent MA (defined as albuminuria excretion rate (AER) = 20-199 microg/min) and renal function (assessed by both eGFR and serum cystatin C). AP and SEVR were each univariately associated with AER, estimated glomerular filtration rate (eGFR) and cystatin C. Lower SEVR was also independently related to the presence of MA and degree of albuminuria within normo- and microalbuminuric participants. SEVR, not AP, was independently and negatively associated with both measures of renal function. SEVR is a better predictor of AER than brachial blood pressure measures in those without clinical proteinuria, indicating a potential use for PWA in the early detection of individuals at risk for cardiovascular and renal complications of T1D.
Authors:
Catherine T Prince; Aaron M Secrest; Rachel H Mackey; Vincent C Arena; Lawrence A Kingsley; Trevor J Orchard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-06
Journal Detail:
Title:  Diabetes & vascular disease research : official journal of the International Society of Diabetes and Vascular Disease     Volume:  7     ISSN:  1752-8984     ISO Abbreviation:  Diab Vasc Dis Res     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-08-11     Completed Date:  2010-11-22     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101234011     Medline TA:  Diab Vasc Dis Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  216-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Albuminuria / etiology*,  metabolism,  physiopathology
Biological Markers / blood,  urine
Blood Pressure*
Brachial Artery / physiopathology*
Cardiovascular Diseases / etiology*,  metabolism,  physiopathology
Chi-Square Distribution
Coronary Circulation*
Cross-Sectional Studies
Cystatin C / blood
Diabetes Mellitus, Type 1 / complications*,  metabolism,  physiopathology
Diabetic Nephropathies / etiology*,  metabolism,  physiopathology
Disease Progression
Elasticity
Female
Glomerular Filtration Rate
Humans
Kidney / physiopathology*
Linear Models
Logistic Models
Male
Manometry
Middle Aged
Nephelometry and Turbidimetry
Odds Ratio
Pennsylvania
Risk Assessment
Risk Factors
Sphygmomanometers
Time Factors
Grant Support
ID/Acronym/Agency:
F30 DK082137/DK/NIDDK NIH HHS; F30 DK082137-02/DK/NIDDK NIH HHS; F30-DK082137/DK/NIDDK NIH HHS; R01 DK034818/DK/NIDDK NIH HHS; R01 DK034818-22/DK/NIDDK NIH HHS; R01-DK034818/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CST3 protein, human; 0/Cystatin C
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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