| Augmentation of methamphetamine-induced behaviors in transgenic mice lacking the trace amine-associated receptor 1. | |
| | |
MedLine Citation:
|
PMID: 22079347 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor that is functionally activated by amphetamine-based psychostimulants, including amphetamine, methamphetamine and MDMA. Previous studies have shown that in transgenic mice lacking the TAAR1 gene (TAAR1 knockout; KO) a single injection of amphetamine can produce enhanced behavioral responses compared to responses evoked in wild-type (WT) mice. Further, the psychostimulant effects of cocaine can be diminished by selective activation of TAAR1. These findings suggest that TAAR1 might be implicated in the rewarding properties of psychostimulants. To investigate the role of TAAR1 in the rewarding effects of drugs of abuse, the psychomotor stimulating effects of amphetamine and methamphetamine and the conditioned rewarding effects of methamphetamine and morphine were compared between WT and TAAR1 KO mice. In locomotor activity studies, both single and repeated exposure to d-amphetamine or methamphetamine generated significantly higher levels of total distance traveled in TAAR1 KO mice compared to WT mice. In conditioned place preference (CPP) studies, TAAR1 KO mice acquired methamphetamine-induced CPP earlier than WT mice and retained CPP longer during extinction training. In morphine-induced CPP, both WT and KO genotypes displayed similar levels of CPP. Results from locomotor activity studies suggest that TAAR1 may have a modulatory role in the behavioral sensitization to amphetamine-based psychostimulants. That methamphetamine-but not morphine-induced CPP was augmented in TAAR1 KO mice suggests a selective role of TAAR1 in the conditioned reinforcing effects of methamphetamine. Collectively, these findings provide support for a regulatory role of TAAR1 in methamphetamine signaling. |
| | |
Authors:
|
Cindy Achat-Mendes; Laurie J Lynch; Katherine A Sullivan; Eric J Vallender; Gregory M Miller |
Related Documents
:
|
19376187 - Attenuation of delayed-type hypersensitivity by fullerene treatment. 3484487 - Increased susceptibility of old mice to plasmacytoma induction. 10395687 - Lack of j chain inhibits the transport of gut iga and abrogates the development of inte... 11474777 - Anti-drug antibodies as drug carriers. i. for small molecules. 9087177 - Hyperosmotic stress as a stimulant for proinflammatory cytokine production. 9209717 - The effects of 50 hz magnetic field exposure on dimethylbenz(alpha)anthracene induced t... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2011-11-04 |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 101 ISSN: 1873-5177 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 2012 Apr |
Date Detail:
|
Created Date: 2012-02-24 Completed Date: 2012-09-24 Revised Date: 2013-04-03 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: United States |
Other Details:
|
Languages: eng Pagination: 201-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Division of Neuroscience, New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, United States. cindy_achat-mendes@hms.harvard.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Conditioning (Psychology) / drug effects Dose-Response Relationship, Drug Male Methamphetamine / pharmacology* Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Motor Activity / drug effects* Receptors, G-Protein-Coupled / deficiency*, genetics |
| Grant Support | |
ID/Acronym/Agency:
|
DA025697/DA/NIDA NIH HHS; K02 DA025697/DA/NIDA NIH HHS; K02 DA025697-01A1/DA/NIDA NIH HHS; RR00168/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, G-Protein-Coupled; 0/Trace amine-associated receptor 1; 537-46-2/Methamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exercise-induced galanin release facilitated GLUT4 translocation in adipocytes of type 2 diabetic ra...
Next Document: Tolerance to cocaine's effects on schedule-controlled behavior: Role of delay between pause-ending r...