| Augmentation of intrapericardial nitric oxide level by a prolonged-release nitric oxide donor reduces luminal narrowing after porcine coronary angioplasty. | |
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MedLine Citation:
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PMID: 12057994 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Nitric oxide (NO) is a potent vasodilator and antiplatelet agent that suppresses vascular smooth muscle cell proliferation. Hypothesizing that generating NO in the pericardial space would reduce luminal narrowing after coronary angioplasty without affecting systemic hemodynamics, we have determined the effect of a novel NO donor on vascular healing after balloon overstretch. METHODS AND RESULTS: Diazeniumdiolated bovine serum albumin (D-BSA; molecular weight 74 kDa, half-life for NO release 20 days) was radioiodinated and found by intravital gamma-imaging to have a longer residence time in pig pericardium than a low-molecular-weight (0.5 kDa) analogue (22 versus 4.6 hours, respectively). Intrapericardial injection of D-BSA immediately before 30% overstretch of normal left anterior descending and left circumflex coronary arteries dose dependently reduced the intimal/medial area ratio by up to 50% relative to controls treated with underivatized albumin when measured 2 weeks after intervention. Positive remodeling was also noted, which increased luminal area relative to control. CONCLUSIONS: Perivascular exposure of coronary arteries to NO via intrapericardial D-BSA administration reduced flow-restricting lesion development after angioplasty in pigs without causing significant systemic effects. The data suggest that intrapericardial delivery of NO donors for which NO release rates and pericardial residence times are matched and optimized might be a beneficial adjunct to coronary angioplasty. |
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Authors:
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Sang Hong Baek; Joseph A Hrabie; Larry K Keefer; Dongming Hou; Naomi Fineberg; Rodney Rhoades; Keith L March |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 105 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-06-11 Completed Date: 2002-06-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
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Languages: eng Pagination: 2779-84 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Division of Cardiology, Indiana University Medical Center, Indianapolis, Ind, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angioplasty, Transluminal, Percutaneous Coronary
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adverse effects* Animals Coronary Restenosis / etiology, metabolism, pathology, prevention & control* Delayed-Action Preparations Dose-Response Relationship, Drug Nitric Oxide / biosynthesis Nitric Oxide Donors / administration & dosage, pharmacokinetics, pharmacology* Pericardium / metabolism* Polyamines / administration & dosage, pharmacology Serum Albumin, Radio-Iodinated / administration & dosage, pharmacokinetics, pharmacology* Swine |
| Grant Support | |
ID/Acronym/Agency:
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N01-CO-56000/CO/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/(131)I-labeled diazeniumdiolated albumin; 0/Delayed-Action Preparations; 0/Nitric Oxide Donors; 0/Polyamines; 0/Serum Albumin, Radio-Iodinated; 10102-43-9/Nitric Oxide; 111-40-0/diethylenetriamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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