| Augmentation of chemokine production by severe acute respiratory syndrome coronavirus 3a/X1 and 7a/X4 proteins through NF-kappaB activation. | |
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MedLine Citation:
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PMID: 17141229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Severe acute respiratory syndrome (SARS) is characterized by rapidly progressing respiratory failure resembling acute/adult respiratory distress syndrome (ARDS) associated with uncontrolled inflammatory responses. Here, we demonstrated that, among five accessory proteins of SARS coronavirus (SARS-CoV) tested, 3a/X1 and 7a/X4 were capable of activating nuclear factor kappa B (NF-kappaB) and c-Jun N-terminal kinase (JNK), and significantly enhanced interleukin 8 (IL-8) promoter activity. Furthermore, 3a/X1 and 7a/X4 expression in A549 cells enhanced production of inflammatory chemokines that were known to be up-regulated in SARS-CoV infection. Our results suggest potential involvement of 3a/X1 and 7a/X4 proteins in the pathological inflammatory responses in SARS. |
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Authors:
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Noriyuki Kanzawa; Kazuo Nishigaki; Takaya Hayashi; Yuichi Ishii; Souichi Furukawa; Ayako Niiro; Fumihiko Yasui; Michinori Kohara; Kouichi Morita; Kouji Matsushima; Mai Quynh Le; Takao Masuda; Mari Kannagi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-27 |
Journal Detail:
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Title: FEBS letters Volume: 580 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-12-20 Completed Date: 2007-01-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 6807-12 Citation Subset: IM |
Affiliation:
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Department of Immunotherapeutics, Tokyo Medical and Dental University, Graduate School, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Chemokines / biosynthesis* Enzyme Activation Gene Expression Humans JNK Mitogen-Activated Protein Kinases / metabolism NF-kappa B / metabolism* Promoter Regions, Genetic / genetics SARS Virus / genetics, metabolism* Viral Matrix Proteins / genetics, metabolism* Viral Proteins / genetics, metabolism* Viral Structural Proteins / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/NF-kappa B; 0/ORF3A protein, SARS coronavirus; 0/Viral Matrix Proteins; 0/Viral Proteins; 0/Viral Structural Proteins; 0/sars7a protein, SARS virus; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases |
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