| Augmentation of central arterial pressure in adult patients after coarctation repair. | |
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MedLine Citation:
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PMID: 21284131 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVES: Arterial hypertension and its complications are associated with an increased morbidity and mortality in patients after aortic coarctation (CoA) repair. It is debatable whether early surgery can prevent it. Residual stenosis of descending aorta (AoD) and stiffness in the precoarctation region supposedly lead to hypertension. The aim of this study was to evaluate aortic pulse-wave parameters in adult patients after CoA repair and to determine the influence of residual stenosis and age at operation on their values. METHODS: Eighty-five patients underwent CoA repair (53 males; aged 34.6±10.3 years, age at operation: 10.9±8.2 years). The control group consisted of 30 individuals (18 males; aged 33.6±8.2 years). Augmentation pressure (AP), augmentation index (AI), aortic pulse pressure (APP), and pulse-wave velocity (PWV) were measured with applanation tonometry method. RESULTS: Normotensive patients after CoA repair (47/55%) had higher values of AP (7.3±4.6 vs. 4.4±3.6 mmHg; P=0.002), AI (18.6±10.4 vs. 13.5±4.3%; P=0.03), APP (39.6±8.8 vs. 35.1±9.8; P=0.00001), and PWV (6.8±1.2 vs. 5.4±0.9 m/s; P=0.003) than controls. Forty-six patients presented signs of recoarctation. No significant differences in the systolic blood pressure and diastolic blood pressure, AI and PWV were found between AoD(+) and AoD(-) but AoD(+) had significantly higher APP (46.7±13.8 vs. 38.3±6.9; P=0.001) and AP (10.5±6.9 vs. 7.5±4.1; P=0.02). Significant correlations were found between current age and APP, AP, and AI. No significant correlations were found between central parameters and the age at operation. CONCLUSION: Normotensive patients after CoA repair have elevated central parameters, related to the residual AoD gradient, regardless of the age at operation. Even early repair cannot prevent progressive vascular impairment in CoA. |
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Authors:
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Ludwina Szczepaniak-Chicheł; Olga Trojnarska; Katarzyna Mizia-Stec; Marcin Gabriel; Stefan Grajek; Zbigniew Gasior; Lucyna Kramer; Andrzej Tykarski |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood pressure monitoring Volume: 16 ISSN: 1473-5725 ISO Abbreviation: Blood Press Monit Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606438 Medline TA: Blood Press Monit Country: England |
Other Details:
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Languages: eng Pagination: 22-8 Citation Subset: IM |
Affiliation:
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First Department of Cardiology, Department of Hypertensiology, Angiology and Internal Medicine, University of Medical Sciences in Poznań, ul. Długa 1/2, Poznań, Poland. szczepaniak-chichel@o2.pl |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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