Document Detail

Augmentation index and large-artery remodeling in patients with longstanding rheumatoid arthritis compared with healthy controls.
MedLine Citation:
PMID:  18823647     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: There is growing evidence of premature atherosclerosis in patients with rheumatoid arthritis (RA), leading to a higher rate of cardiovascular events than in the general population. The augmentation index (AIx), a marker of arterial stiffness, is an indicator of vascular function. The aim of the study was as follows: (1) to investigate whether AIx is increased in RA patients without traditional cardiovascular risk factors and (2) to evaluate whether there is an interrelationship with large artery remodeling as ascertained by carotid ultrasound. METHODS: Thirty-six RA patients (age, 46.4 +/- 7.7 years; 31 female) were recruited. Patients were eligible for analysis if they had no traditional cardiovascular risk factors. AIx was assessed noninvasively during pulse wave analyses. For large artery remodeling the intima-media thickness (IMT) was measured in both common carotid arteries with ultrasound. Results were compared with 36 age- and sex-matched controls. RESULTS: AIx was statistically significantly higher in RA patients as compared with controls (27.4 +/- 9.4% versus 18.4 +/- 9.0%; P < 0.001). In addition, IMT was significantly higher in RA patients (0.73 +/- 0.16 mm versus 0.65 +/- 0.12 mm; P = 0.01). In RA patients there was a positive correlation between IMT and AIx (r[IMT; AIx] = 0.45; P = 0.008). CONCLUSION: AIx, a marker of arterial stiffness, as well as IMT, a marker of large-artery remodeling, are increased in RA patients without traditional cardiovascular risk factors. Measuring AIx might assist in better assessing the increased cardiovascular risk in RA patients.
Herwig Pieringer; Sabine Schumacher; Ulrike Stuby; Georg Biesenbach
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Publication Detail:
Type:  Journal Article     Date:  2008-09-27
Journal Detail:
Title:  Seminars in arthritis and rheumatism     Volume:  39     ISSN:  1532-866X     ISO Abbreviation:  Semin. Arthritis Rheum.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-11-25     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1306053     Medline TA:  Semin Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  163-9     Citation Subset:  IM    
2nd Department of Medicine, Section of Rheumatology, General Hospital Linz, Linz, Austria.
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MeSH Terms
Arthritis, Rheumatoid / complications,  physiopathology*,  ultrasonography*
Atherosclerosis / epidemiology,  physiopathology,  ultrasonography
Blood Pressure / physiology
Carotid Arteries / ultrasonography*
Case-Control Studies
Cross-Sectional Studies
Elasticity / physiology*
Middle Aged
Radial Artery / physiopathology*
Risk Factors
Tunica Intima / ultrasonography
Tunica Media / ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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