| Augmentation Index Immediately After Maximal Exercise in Type 2 Diabetic Patients. | |
| | |
MedLine Citation:
|
PMID: 21685818 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
INTRODUCTION:: Patients with type 2 diabetes (T2DM) have exaggerated brachial and central (ascending aortic) blood pressure (BP) during exercise, which is associated with adverse outcomes. Central systolic loading, represented by the augmentation index (AIx), may contribute to exaggerated exercise central BP. This study sought to compare the central AIx response to peak exercise in T2DM and control patients and identify mechanisms of altered exercise central AIx. METHODS:: Central BP and AIx were quantified by radial tonometry at rest and immediately following peak treadmill exercise in 106 patients with T2DM and 106 nondiabetic controls, pair-matched by age, gender, peak exercise brachial BP and the post-exercise heart rate (HR) corresponding to tonometry acquisition. Cardiac volumes (by echocardiography) were assessed in a subgroup (22 T2DM and 22 controls) to derive rest and post-exercise arterial-ventricular coupling parameters, including cardiac index (stroke volume index×HR), peripheral vascular resistance index (PVRI; cardiac index/mean BP), and effective arterial elastance index (EaI; end systolic pressure/stroke volume index). Reserve parameters (exercise - rest) were also defined. RESULTS:: Patients with T2DM had lower post-exercise central AIx (-1±13% vs. 3±14%; p=0.038) and greater central AIx reserve (-24±13% vs. -20±11%; p=0.002) compared with controls, despite raised post-exercise PVRI (p=0.013) and EaI (p=0.011); these parameters independently predicted higher central AIx at rest (p<0.01), but not post-exercise. Moreover, T2DM was independently associated with lower post-exercise central AIx (β=-0.19, p=0.01). Cardiac index reserve, which was blunted in T2DM (p=0.004), represented the only independent correlate of central AIx reserve (r=0.39, p=0.01). CONCLUSION:: Patients with T2DM have significantly (and paradoxically) lower post-exercise central AIx and greater central AIx reserve, which may be explained by impaired cardiac functional reserve. |
| | |
Authors:
|
Julian W Sacre; David J Holland; Carly Jenkins; James E Sharman |
Related Documents
:
|
10365988 - Physical exercise as a modulator of adaptation to low and high carbohydrate and low and... 22008208 - Effects of oxygen on exertional dyspnoea and exercise performance in patients with chro... 4044828 - Thermic effect of food at rest, during exercise, and after exercise in lean and obese m... 19375588 - Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptatio... 2262468 - Hormonal and growth factor responses to heavy resistance exercise protocols. 11092108 - Bisoprolol alone and in combination with amlodipine or nifedipine in the treatment of c... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-6-16 |
Journal Detail:
|
Title: Medicine and science in sports and exercise Volume: - ISSN: 1530-0315 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-6-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8005433 Medline TA: Med Sci Sports Exerc Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1Schools of Medicine and 2Human Movement Studies, The University of Queensland, Brisbane, AUSTRALIA. 3Menzies Research Institute, University of Tasmania, Hobart, AUSTRALIA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Exercise Does Not Attenuate Early Coronary Artery Disease Progression in a Pig Model.
Next Document: Water Ingestion Improves Performance Compared to Mouth-Rinse, in Dehydrated Subjects.