Document Detail

Auditory threshold reduction on alcohol ingestion.
MedLine Citation:
PMID:  11594444     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Auditory threshold (AT) measurement method has become the standard behavioral procedure for describing auditory sensitivity. Therefore, the AT measurement method is applicable to evaluation of auditory function. However, only a few studies have been performed to clarify the alteration of audibility under the influence of alcohol on normal humans by measurement of AT.
OBJECTIVE: The fact that blood alcohol concentration (BAC) is influenced by the dose of alcohol and the time of measurement suggests that the effects of alcohol may also be altered by the same factors. The present study was conducted to elucidate how alcohol ingestion method affects the AT at a wider range from lower to higher frequency in the time course.
METHODS: Fifteen paid Japanese (seven men and eight women, 20-33 years of age) were employed in AT measurements at an octave frequency ranging from 250 to 8,000 Hz before and 5, 30, 60, 120, 240 and 480 min after drinking various amounts (125, 250, 500 and 1,500 ml) of normal beer (5% alcohol) or alcohol-free beer.
RESULTS: The AT was significantly reduced within 30 min after the ingestion of 250 and 500 ml of beer, occurring on and after peak BAC. The reducing effect disappeared 480 min after ingestion.
CONCLUSIONS: Drinking extra small amounts of alcohol induces the reduction of AT. The effect of alcohol on AT is altered by the alcoholic dose used in testing.
K Murata; M Kawashima; R Inaba
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychopharmacology     Volume:  157     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-10-11     Completed Date:  2002-02-26     Revised Date:  2014-07-28    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  188-92     Citation Subset:  IM    
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MeSH Terms
Alcohol Drinking* / blood
Analysis of Variance
Auditory Threshold / drug effects*,  physiology
Central Nervous System Depressants / blood,  pharmacology*
Dose-Response Relationship, Drug
Ethanol / blood,  pharmacology*
Reg. No./Substance:
0/Central Nervous System Depressants; 3K9958V90M/Ethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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