Document Detail

Auditory stimulation alters the pattern of 2-deoxyglucose uptake in the inner ear.
MedLine Citation:
PMID:  7059827     Owner:  NLM     Status:  MEDLINE    
The 2-deoxy-D-glucose (2-DG) autoradiographic technique was adapted for application to the inner ear. The uptake of [14C]-DG during silence was compared with that observed during exposure to wide band noise (WBN) or pure tones at an intensity level of 85 db SPL. In silence, the highest levels of 2-DG uptake were observed in the spiral ligament, spiral prominence and stria vascularis, with approximately equal levels of uptake in each structure. The high levels of 2-DG uptake observed in the ligament and prominence are surprising, and suggest a more active role for these structures in cochlear function than has previously been suspected. Levels of uptake in the organ of Corti, spiral ganglion and VIIIth nerve were much lower, although well above background. During exposure to WBN, 2-DG uptake increased markedly in the VIIIth nerve, and spiral ganglion throughout the cochlea, and in the organ of Corti in the lower basal turn. 2-DG uptake did not change significantly in the spiral ligament or stria vascularis. During pure tone exposure, increased 2-DG uptake was noted in localized regions of the VIIIth nerve and spiral ganglion.
A F Ryan; P Goodwin; N K Woolf; F Sharp
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  234     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1982 Feb 
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2013-01-25    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  213-25     Citation Subset:  IM    
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MeSH Terms
Auditory Perception / physiology*
Blood Glucose / metabolism*
Cochlea / innervation
Cochlear Nerve / metabolism
Deoxyglucose / blood
Ear, Inner / innervation*
Evoked Potentials, Auditory
Organ of Corti / innervation
Perilymph / metabolism
Pitch Perception / physiology
Spiral Ganglion / metabolism
Vestibulocochlear Nerve / metabolism
Grant Support
Reg. No./Substance:
0/Blood Glucose; 154-17-6/Deoxyglucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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