Document Detail

Auditory processing in severely brain injured patients: differences between the minimally conscious state and the persistent vegetative state.
MedLine Citation:
PMID:  14967772     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The minimally conscious state (MCS) is a recently defined clinical condition; it differs from the persistent vegetative state (PVS) by the presence of inconsistent, but clearly discernible, behavioral evidence of consciousness. OBJECTIVE: To study auditory processing among patients who are in an MCS, patients who are in a PVS, and healthy control subjects. METHODS: By means of (15)O-radiolabeled water-positron emission tomography, we measured changes in regional cerebral blood flow induced by auditory click stimuli in 5 patients in an MCS, 15 patients in a PVS, and 18 healthy controls. RESULTS: In both patients in an MCS and the healthy controls, auditory stimulation activated bilateral superior temporal gyri (Brodmann areas 41, 42, and 22). In patients in a PVS, the activation was restricted to Brodmann areas 41 and 42 bilaterally. We also showed that, compared with patients in a PVS, patients in an MCS demonstrated a stronger functional connectivity between the secondary auditory cortex and temporal and prefrontal association cortices. CONCLUSIONS: Although assumptions about the level of consciousness in severely brain injured patients are difficult to make, our findings suggest that the cerebral activity observed in patients in an MCS is more likely to lead to higher-order integrative processes, thought to be necessary for the gain of conscious auditory perception.
Mélanie Boly; Marie-Elisabeth Faymonville; Philippe Peigneux; Bernard Lambermont; Pierre Damas; Guy Del Fiore; Christian Degueldre; Georges Franck; André Luxen; Maurice Lamy; Gustave Moonen; Pierre Maquet; Steven Laureys
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of neurology     Volume:  61     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-02-17     Completed Date:  2004-03-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  233-8     Citation Subset:  AIM; IM    
Cyclotron Research Center, University of Liège, Liège, Belgium.
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MeSH Terms
Acoustic Stimulation
Auditory Perception / physiology*
Brain Injuries / psychology*
Cerebrovascular Circulation / physiology
Consciousness / physiology*
Middle Aged
Oxygen Radioisotopes / diagnostic use
Persistent Vegetative State / physiopathology,  psychology*
Tomography, Emission-Computed
Reg. No./Substance:
0/Oxygen Radioisotopes

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