Document Detail

Auditory neuropathy in a patient exposed to xylene: case report.
MedLine Citation:
PMID:  18439334     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report the case of an adult patient who developed auditory complaints following xylene exposure, and to review the literature on the effects of solvent exposure on hearing. CASE REPORT: The patient presented with a gradual deterioration in his ability to hear in difficult acoustic environments and also to hear complex sounds such as music, over a 40-year period. His symptoms began following exposure to the solvent xylene, and in the absence of any other risk factor. Our audiological investigations revealed normal otoacoustic emissions with absent auditory brainstem responses and absent acoustic reflexes in both ears, consistent with a diagnosis of bilateral auditory neuropathy. Central test results were also abnormal, indicating possible involvement of the central auditory pathway. CONCLUSIONS: To our knowledge, this is the first report of retrocochlear hearing loss following xylene exposure. The test results may provide some insight into the effect of xylene as an isolated agent on the human auditory pathway.
T H J Draper; D-E Bamiou
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2008-04-28
Journal Detail:
Title:  The Journal of laryngology and otology     Volume:  123     ISSN:  1748-5460     ISO Abbreviation:  J Laryngol Otol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-08-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8706896     Medline TA:  J Laryngol Otol     Country:  England    
Other Details:
Languages:  eng     Pagination:  462-5     Citation Subset:  AIM; IM    
Audiology Department, Royal Sussex County Hospital, Brighton, UK.
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MeSH Terms
Audiometry, Pure-Tone
Hearing Loss, Sensorineural / chemically induced*
Middle Aged
Occupational Exposure / adverse effects*
Retrocochlear Diseases / chemically induced*
Solvents / toxicity*
Xylenes / toxicity*
Reg. No./Substance:
0/Solvents; 0/Xylenes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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