Document Detail


Auditory nerve fibre responses in the ferret.
MedLine Citation:
PMID:  22694786     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ferret (Mustela putorius) is a medium-sized, carnivorous mammal with good low-frequency hearing; it is relatively easy to train, and there is therefore a good body of behavioural data detailing its detection thresholds and localization abilities. However, despite extensive studies of the physiology of the central nervous system of the ferret, even extending to the prefrontal cortex, little is known of the functioning of the auditory periphery. Here, we provide an insight into this peripheral function by detailing responses of single auditory nerve fibres. Our expectation was that the ferret auditory nerve responsiveness would be similar that of its near relative, the cat. However, by comparing a range of variables (the frequency tuning, the variation of rate-level functions with spontaneous rate, and the high-frequency cut-off of phase locking) across several species, we show that the auditory nerve (and hence cochlea) in the ferret is more similar to that of the guinea-pig and chinchilla than to that of the cat. Animal models of hearing are often chosen on the basis of the similarity of their audiogram to that of the human, particularly in the low-frequency region. We show here that whereas the ferret hears well at low frequencies, this is likely to occur via fibres with higher characteristic frequencies. These qualitative differences in response characteristics in auditory nerve fibres are important in interpreting data across all of auditory science, as it has been argued recently that tuning in animals is broader than in humans.
Authors:
Christian J Sumner; Alan R Palmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-14
Journal Detail:
Title:  The European journal of neuroscience     Volume:  36     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-21     Completed Date:  2012-12-20     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  2428-39     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors. European Journal of Neuroscience © 2012 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation
Animals
Cochlear Nerve / physiology*
Evoked Potentials, Auditory
Ferrets
Nerve Fibers / physiology*
Species Specificity
Grant Support
ID/Acronym/Agency:
MC_U135097126//Medical Research Council; MC_U135097127//Medical Research Council; //Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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