Document Detail

Auditory middle latency responses in patients with epilepsy.
MedLine Citation:
PMID:  8045251     Owner:  NLM     Status:  MEDLINE    
Middle latency auditory responses (MLRs) were studied in 55 normal subjects and 49 epileptic patients. We evaluated the function of the auditory system and of the temporal lobe in epileptic patients using MLRs. (1) The patients with epilepsy had significantly prolonged Pa and Nb latencies and the significantly increased amplitude of Pa-Nb component. (2) The prolongation and the increase of MLR components in latency and amplitude were more obvious in patients with intractable epilepsy than patients without intractable epilepsy. (3) The difference between left and right sides was larger in epileptic patients than normal subjects. (4) Epileptic patients with polypharmacy had reduced amplitude of Pa-Nb component and prolonged latency of Pa component than patients with monotherapy. Antiepileptic drugs (AEDs) appeared to decrease the amplitude of Pa-Nb component. It was supposed that the enhancement of amplitude of Pa-Nb component represented the abnormality of central nerve system in epileptic patients, in part.
T Azumi; K Nakashima; K Takahashi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Electromyography and clinical neurophysiology     Volume:  34     ISSN:  0301-150X     ISO Abbreviation:  Electromyogr Clin Neurophysiol     Publication Date:    1994 Apr-May
Date Detail:
Created Date:  1994-08-30     Completed Date:  1994-08-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0327533     Medline TA:  Electromyogr Clin Neurophysiol     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  185-91     Citation Subset:  IM    
Division of Neurology, Tottori University School of Medicine, Yonago, Japan.
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MeSH Terms
Age Factors
Anticonvulsants / administration & dosage,  therapeutic use
Auditory Pathways / physiopathology
Drug Combinations
Epilepsies, Partial / physiopathology
Epilepsy / drug therapy,  physiopathology*
Epilepsy, Generalized / physiopathology
Evoked Potentials, Auditory / drug effects,  physiology*
Middle Aged
Reaction Time / drug effects,  physiology*
Temporal Lobe / physiopathology
Reg. No./Substance:
0/Anticonvulsants; 0/Drug Combinations

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