| Auditory hair cell precursors immortalized from the mammalian inner ear. | |
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MedLine Citation:
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PMID: 9753783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mammalian auditory hair cells are few in number, experimentally inaccessible, and do not proliferate postnatally or in vitro. Immortal cell lines with the potential to differentiate into auditory hair cells would substantially facilitate auditory research, drug development, and the isolation of critical molecules involved in hair cell biology. We have established two conditionally immortal cell lines that express at least five characteristic hair cell markers. These markers are the transcription factor Brn3.1, the alpha 9 subunit of the acetylcholine receptor, the stereociliary protein fimbrin and the myosins VI and VIIA. These hair cell precursors permit functional studies of cochlear genes and in the longer term they will provide the means to explore therapeutic methods of stimulating auditory hair cell regeneration. |
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Authors:
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M N Rivolta; N Grix; P Lawlor; J F Ashmore; D J Jagger; M C Holley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Proceedings. Biological sciences / The Royal Society Volume: 265 ISSN: 0962-8452 ISO Abbreviation: Proc. Biol. Sci. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1998-11-19 Completed Date: 1998-11-19 Revised Date: 2012-07-11 |
Medline Journal Info:
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Nlm Unique ID: 101245157 Medline TA: Proc Biol Sci Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1595-603 Citation Subset: IM |
Affiliation:
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Department of Physiology, School of Medical Sciences, University of Bristol, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Line, Transformed* DNA-Binding Proteins / biosynthesis Dyneins Epithelial Cells / metabolism Female Hair Cells, Auditory / cytology*, metabolism Male Membrane Glycoproteins / biosynthesis Mice Mice, Inbred C57BL Microfilament Proteins* Myosin Heavy Chains / biosynthesis Myosins / biosynthesis Receptors, Cholinergic / biosynthesis Stem Cells / cytology, metabolism Transcription Factor Brn-3 Transcription Factor Brn-3A Transcription Factors / biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
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//Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Membrane Glycoproteins; 0/Microfilament Proteins; 0/Myosin Heavy Chains; 0/Pou4f1 protein, mouse; 0/Receptors, Cholinergic; 0/Transcription Factor Brn-3; 0/Transcription Factor Brn-3A; 0/Transcription Factors; 0/myosin VI; 0/plastin; EC 3.6.4.1/Myosins; EC 3.6.4.1/myosin VIIa; EC 3.6.4.2/Dyneins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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