Document Detail

Auditory filter shapes of CBA/CaJ mice: behavioral assessments.
MedLine Citation:
PMID:  16875229     Owner:  NLM     Status:  MEDLINE    
Auditory filter shape and frequency tuning may be derived by measuring changes in pure tone thresholds as a function of the bandwidth of notched-noise maskers. When these psychophysical methods were applied to CBA/CaJ mice, the resulting filter shapes were well fit by roex(p,r) functions originally developed for human subjects. The equivalent rectangular bandwidths (ERBs) of the filter shapes ranged from 16 to 19% of test frequencies between 8 to 16 kHz. These ERBs correspond well to the performance of humans at high frequencies and the limited number of mammalian species that have been characterized with notched-noise procedures. Frequency tuning was maintained throughout most of the adult lifespan and then showed a selective high-frequency loss at ages beyond 2 years. These results suggest that auditory filtering effects in adult CBA/CaJ mice are similar to normal processes in other mammalian species and provide an excellent model of human presbycusis when they begin to degrade in aging individuals.
Bradford J May; Sarah Kimar; Cynthia A Prosen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  120     ISSN:  0001-4966     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-31     Completed Date:  2008-01-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  321-30     Citation Subset:  IM    
The Center for Hearing and Balance, Department of Otolarygnology-HNS, Johns Hopkins University, Baltimore, Maryland 21205, USA.
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MeSH Terms
Audiometry, Pure-Tone
Auditory Threshold / physiology*
Behavior, Animal
Conditioning (Psychology)*
Disease Models, Animal
Evoked Potentials, Auditory, Brain Stem
Mice, Inbred CBA
Presbycusis / physiopathology*
Grant Support

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