| Auditory-evoked response analysis in Brazilian patients with sickle cell disease. | |
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MedLine Citation:
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PMID: 20180627 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The objective of the present study was to evaluate the integrity of the peripheral and central auditory systems of sickle cell disease (SCD) patients, through electrophysiological evaluation utilizing auditory evoked potentials, and comparing the results obtained in SCD patients with individuals without SCD. A total of 80 individuals were evaluated: 40 SCD patients; and 40 healthy age- and sex-matched controls. Brainstem auditory evoked response (BAER) was used to check neural integrity and electrophysiological thresholds, and cognitive potential (P300) to analyse the auditory selective attention. Despite the exclusion of individuals with comorbidities typical of SCD, the predominance of hearing loss among the patients was detected in 16 ears (20%). The absolute latencies of the BAER were within the expected range but the SCD group showed a small but statistically significant reduction of the interpeaks I-V, indicative of cochlear alteration. P300 latency and amplitude were adequate for both groups suggesting the absence of central auditory system abnormalities. The present findings suggest that SCD causes variable degree of cochlear abnormalities without evidence of neural problems. |
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Authors:
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Isabella Monteiro de Castro Silva; Isis Quezado Magalh?es; Raquel Alves Toscano; Lenora Gandolfi; Riccardo Pratesi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of audiology Volume: 49 ISSN: 1708-8186 ISO Abbreviation: Int J Audiol Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-17 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140017 Medline TA: Int J Audiol Country: England |
Other Details:
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Languages: eng Pagination: 272-6 Citation Subset: IM |
Affiliation:
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Centro Universit?rio Planalto do Distrito Federal-UNIPLAN-Audiology Unit, Brasilia, DF, Brazil. isabella.monts@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Impedance Tests Acoustic Stimulation Adolescent Anemia, Sickle Cell / complications, physiopathology* Auditory Pathways / physiopathology* Brazil Case-Control Studies Child Cochlea / physiopathology Cognition Event-Related Potentials, P300 Evoked Potentials, Auditory, Brain Stem* Female Hearing Loss / etiology*, physiopathology Humans Male Reaction Time Reflex, Acoustic Severity of Illness Index Synaptic Transmission Time Factors Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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