Document Detail


Auditory evoked potentials in the assessment of central nervous system effects of antimigraine drugs.
MedLine Citation:
PMID:  10668107     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because the "intensity dependence" of cortical auditory evoked potentials (IDAP) is under serotonergic control, it can be used to assess central antimigraine effects of 5HT1B/1D agonists. We measured IDAP before and 2 h after naratriptan (5 mg, n = 19) and zolmitriptan (5 mg, n = 19) in healthy volunteers. IDAP was expressed as the amplitude-stimulus intensity function ("ASF slope"). Naratriptan tended to increase ASF slope (mean difference 0.23 +/- 0.62 microV/10 dB, p = 0.06) while zolmitriptan (0.08 +/- 0.95 microV/10 dB, p = 0.35) did not. We assessed the suitability of IDAP for measuring central antimigraine drug effects using repeatability data (see companion paper). We calculated the trade-off between the size of the expected drug effects (ASF slope difference) and the necessary sample size. Because of poor repeatability 36 to 80 subjects are required to detect ASF slope changes in the 0.25-0.5 microV/10 dB range. These data can be used to design trials using IDAP.
Authors:
K I Roon; P S Sándor; G G Schoonman; F P Lamers; J Schoenen; M D Ferrari; J G van Dijk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cephalalgia : an international journal of headache     Volume:  19     ISSN:  0333-1024     ISO Abbreviation:  Cephalalgia     Publication Date:  1999 Dec 
Date Detail:
Created Date:  2000-03-14     Completed Date:  2000-03-14     Revised Date:  2008-02-11    
Medline Journal Info:
Nlm Unique ID:  8200710     Medline TA:  Cephalalgia     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  880-5     Citation Subset:  IM    
Affiliation:
Department of Neurology and Clinical Neurophysiology, Leiden University Medical Centre, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cerebral Cortex / drug effects*,  physiology
Evoked Potentials, Auditory / drug effects*
Female
Humans
Indoles / pharmacology*
Male
Oxazoles / pharmacology*
Oxazolidinones*
Piperidines / pharmacology*
Reproducibility of Results
Sample Size
Serotonin Agonists / pharmacology*
Tryptamines
Chemical
Reg. No./Substance:
0/Indoles; 0/Oxazoles; 0/Oxazolidinones; 0/Piperidines; 0/Serotonin Agonists; 0/Tryptamines; 121679-13-8/naratriptan; 139264-17-8/zolmitriptan

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