| Auditory cortex lesions in the rat impair both temporal acuity and noise increment thresholds, revealing a common neural substrate. | |
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MedLine Citation:
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PMID: 12853367 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Temporal acuity for acoustic transients in rats with bilateral auditory cortex lesions (n = 6) was compared with that of sham-surgery control rats (n = 4), using a standard gap-detection method. A comparison of sensitivity to quiet gaps in noise and dark gaps in light tested for a cross-modal effect of the lesion. The groups were compared also in their sensitivity to noise offset, to noise increments, and to noise pulses presented in quiet. Stimulus detection was assessed with the startle reflex modification procedure, which uses changes in reflex expression caused by stimuli presented immediately before reflex elicitation as the objective evidence for their detection. There were no group differences in sensitivity to noise offset, noise pulses, or dark gaps in light. In contrast, the lesion reduced sensitivity to noise increments and eliminated gap detection. These deficits were maintained for 1 month and only partially recovered 2 months after surgery. The data indicate that the auditory cortex is critically important for temporal acuity in hearing, and suggest that its contribution to gap detection is to enhance the salience of noise increments at the end of the gap. |
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Authors:
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G Peter Bowen; Daniel Lin; Merritt K Taylor; James R Ison |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Cerebral cortex (New York, N.Y. : 1991) Volume: 13 ISSN: 1047-3211 ISO Abbreviation: Cereb. Cortex Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-07-10 Completed Date: 2003-09-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9110718 Medline TA: Cereb Cortex Country: United States |
Other Details:
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Languages: eng Pagination: 815-22 Citation Subset: IM |
Affiliation:
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Department of Brain and Cognitive Sciences, Meliora Hall, University of Rochester, Rochester, NY 14627, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acoustic Stimulation
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methods* Animals Auditory Cortex / physiology* Auditory Threshold / physiology* Male Rats Rats, Inbred F344 Startle Reaction / physiology Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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AG09524/AG/NIA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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