| Auditory System Dysfunction due to Infantile Thiamine Deficiency: Long-Term Auditory Sequelae. | |
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MedLine Citation:
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PMID: 22739497 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Eleven infants who were fed a thiamine-deficient formula for a mean of 3 months were evaluated for immediate and long-term auditory abnormalities. At presentation, 8 infants had auditory neuropathy spectrum disorder (ANSD), which resolved with supplementary thiamine in 5 children, was permanent in 2 children, and deteriorated in 1 patient who died at the age of 7 years. An additional patient had an auditory pattern corresponding to that of auditory neuropathy of brain stem origin. The 2 remaining patients had unilateral cochlear hearing loss. Six to 8 years later, all patients with transient ANSD had normal audiograms, 2 patients had unilateral cochlear hearing loss, and the rest had neural hearing loss. All survivors had a language developmental delay and impaired speech intelligibility of varying degrees, especially in the presence of background noise. Thiamine is crucial for normal auditory development and function, and its deficiency may be considered an acquired metabolic cause of ANSD in infants. |
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Authors:
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J Attias; E Raveh; A Aizer-Dannon; A Bloch-Mimouni; A Fattal-Valevski |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-27 |
Journal Detail:
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Title: Audiology & neuro-otology Volume: 17 ISSN: 1421-9700 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9606930 Medline TA: Audiol Neurootol Country: - |
Other Details:
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Languages: ENG Pagination: 309-320 Citation Subset: - |
Copyright Information:
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Copyright © 2012 S. Karger AG, Basel. |
Affiliation:
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Department of Communication Sciences and Disorders, University of Haifa, Haifa, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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