| Audit of the use of calcium carbonate as a phosphate binder in 100 patients treated with continuous ambulatory peritoneal dialysis. | |
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MedLine Citation:
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PMID: 1323075 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We studied the effect of converting 100 established CAPD patients from aluminium- to calcium-based phosphate binders. After a follow-up of 1 year only 60% of patients remained on calcium carbonate. Hypercalcaemia was the major problem, with more than 40% of patients having a serum calcium in excess of 3.0 mmol/l. Several patients required hospitalization for symptomatic hypercalcaemia. Hypercalcaemia was more common in patients with normal serum parathyroid hormone concentrations (65 versus 25%, P less than 0.01). Serum phosphate control was better prior to commencing calcium carbonate when patients were treated with aluminium phosphate binders mean 1.71 +/- 0.15 mmol/l (SEM) than at the time of maximum serum calcium concentration, 1.81 +/- 0.25, P less than 0.05. This study does not confirm the findings of others, which have suggested that calcium carbonate is a safe and effective phosphate binder for patients with end-stage renal failure. |
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Authors:
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A Davenport; S Goel; J C MacKenzie |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 7 ISSN: 0931-0509 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-09-10 Completed Date: 1992-09-10 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: GERMANY |
Other Details:
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Languages: eng Pagination: 632-5 Citation Subset: IM |
Affiliation:
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Department of Renal Medicine, Southmead Hospital, Bristol, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Alkaline Phosphatase / blood Calcium / blood Calcium Carbonate / pharmacology* Female Humans Hypercalcemia / etiology Male Middle Aged Peritoneal Dialysis, Continuous Ambulatory* Phosphates / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Phosphates; 471-34-1/Calcium Carbonate; 7440-70-2/Calcium; EC 3.1.3.1/Alkaline Phosphatase |
| Comments/Corrections | |
Comment In:
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Nephrol Dial Transplant. 1993;8(2):188-9
[PMID:
8384346
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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