| Audit of safety and quality of the use of enoxaparin for anticoagulation in continuous renal replacement therapy. | |
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MedLine Citation:
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PMID: 21355825 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the safety and efficacy of enoxaparin for anticoagulation during continuous renal replacement therapy (CRRT). DESIGN: Six-month prospective audit on filter life, anti-Xa activity and bleeding complications among patients undergoing continuous venovenous haemodiafiltration with 1.5mg/kg enoxaparin per 24 hours. The audit was conducted between June and December 2009. RESULTS: Thirteen patients were included. The median overall filter survival time was 22 hours (range, 2-176 hours). Two patients experienced minor bleeding events, but there were no major bleeding events. Systemic activity of enoxaparin was demonstrated, with a significant rise in median anti-Xa activity between assays before and during filtration (0.00 [range, 0.00-0.13] v 0.31 [range, 0.07-1.26] anti-Xa U/mL; P = 0.03). CONCLUSIONS: Enoxaparin at 1.5mg/kg/24 h appears to be effective for circuit anticoagulation in CRRT and provides significant systemic anticoagulation. Further research is required to evaluate its safety, particularly in the absence of routine anti-Xa monitoring. |
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Authors:
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David J Tsang; Annabel Tuckfield; Christopher M Macisaac |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine Volume: 13 ISSN: 1441-2772 ISO Abbreviation: Crit Care Resusc Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-03-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888170 Medline TA: Crit Care Resusc Country: Australia |
Other Details:
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Languages: eng Pagination: 24-7 Citation Subset: IM |
Affiliation:
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Royal Melbourne Hospital, Melbourne, VIC, Australia. djtsang@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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