Document Detail


Audit of initial management of congenital hypothyroidism in the United Kingdom--comparison of UK practice with European and UK guidelines.
MedLine Citation:
PMID:  20101887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Prompt and adequate management of newly diagnosed congenital hypothyroidism (CH) has been shown to optimise intellectual outcome. METHODS: A questionnaire survey of the British Society for Paediatric Endocrinology and Diabetes (BSPED) membership was undertaken, examining current clinical practice in neonatal CH. Results were compared with published management guidelines from Europe and the UK. RESULTS: The response rate was 86%. The majority were largely compliant with both guidelines. 43% review newly referred infants on the day of notification. However, 26% treat severe CH with < 10 microg/kg/day thyroxine and nearly 20% do not follow up until at least 14 days after initiating treatment, in contrast to both guidelines. Despite a new liquid T4 preparation being licensed, respondents preferred tablet T4. CONCLUSION: Rapidity of assessment and adequate follow up of suspected CH is critical to outcome. Existing European and UK guidelines should be reviewed and expanded to incorporate new evidence, together with increased advice on preparation and administration of T4.
Authors:
Jeremy H Jones; Malcolm D C Donaldson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of pediatric endocrinology & metabolism : JPEM     Volume:  22     ISSN:  0334-018X     ISO Abbreviation:  J. Pediatr. Endocrinol. Metab.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-02-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9508900     Medline TA:  J Pediatr Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  1017-25     Citation Subset:  IM    
Affiliation:
Department of Child Health, Royal Hospital for Sick Children, Glasgow, UK. jjones@clinmed.gla.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Congenital Hypothyroidism / diagnosis,  therapy*
Dosage Forms
Early Diagnosis
Great Britain
Guideline Adherence
Hormone Replacement Therapy
Humans
Infant, Newborn
Medical Audit*
Neonatal Screening
Physician's Practice Patterns / statistics & numerical data*
Practice Guidelines as Topic
Questionnaires*
Societies, Medical
Thyroxine / therapeutic use
Chemical
Reg. No./Substance:
0/Dosage Forms; 7488-70-2/Thyroxine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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