Document Detail

Audiovestibular disorders in patients with ankylosing spondylitis.
MedLine Citation:
PMID:  16357708     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Audiovestibular disorders have been described in several autoimmune diseases but have not been studied in patients with ankylosing spondylitis (AS). The aim of this study was to evaluate the audiovestibular function in patients with AS. METHODS: We prospectively evaluated 22 consecutive patients with AS. Clinical, radiologic, and immunogenetic features were analyzed. All patients underwent a complete ear, nose, and throat physical examination and audiologic evaluation that included pure-tone audiometry thresholds at octave frequencies of 250 to 8000 Hz, impedance audiometry (tympanogram, static compliance, acoustic reflexes, and reflex decay), and speech audiometry. Thirty-one healthy volunteers and 26 patients with rheumatoid arthritis (RA) were included as controls. RESULTS: Patients with AS had a median age of 45.5 years (interquartile range [IQR] 38-54) and a median disease duration of 20 years (IQR 12.5-26.2). Otosclerosis was observed in 2 patients with AS (9.1%), 3 patients with RA (11.5%), but not in any healthy controls (P = not significant). Sensorineural hearing loss (SNHL) was observed in 13 patients with AS (59%), 17 patients with RA (65.4%), and 13 healthy controls (41.9%) without statistically significant differences. Because age can influence audiometric results, patients and controls were divided into 4 age groups. A higher frequency of SNHL was observed in patients with AS from 45 to 59 years compared with healthy controls and patients with RA (87% versus 20%, P = 0.03, versus 70%, P = not significant, respectively). CONCLUSION: Middle-aged patients with AS had a significantly higher frequency of SNHL compared with controls. SNHL should be considered as a possible complication of AS as well as of RA and other autoimmune diseases. Possible toxic effect of nonsteroidal antiinflammatory drugs should also be considered in such patients.
Carolina Casellini; Gustavo Citera; Marcos Rosemffet; Santiago Ruggeri; Andrea Saviotti; José A Maldonado Cocco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases     Volume:  11     ISSN:  1076-1608     ISO Abbreviation:  J Clin Rheumatol     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-12-16     Completed Date:  2006-02-28     Revised Date:  2008-04-10    
Medline Journal Info:
Nlm Unique ID:  9518034     Medline TA:  J Clin Rheumatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Section of Rheumatology, Instituto de Rehabilitación Psicofísica, Escheverria 995, 1428 Buenos Aires, Argentina.
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MeSH Terms
Age Factors
Case-Control Studies
Cochlear Nerve / physiopathology*
Hearing Loss, Sensorineural / etiology
Middle Aged
Otosclerosis / etiology
Prospective Studies
Spondylitis, Ankylosing / complications,  physiopathology*
Vestibular Nerve / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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