Document Detail

Audiometric changes in patients undergoing liver transplantation using distinct immunosuppressive protocols.
MedLine Citation:
PMID:  18383080     Owner:  NLM     Status:  MEDLINE    
The aim of the study was to disclose a possible association of hearing defects with the use of either cyclosporin (CyA) or tacrolimus (FK-506) in patients undergoing liver transplantation (LT). Pure-tone audiometry (PTA) was performed in the same 42 patients before and after LT. Audiometric frequencies recorded ranged from 250 to 8000 Hz. Patients were divided into 2 groups according to the use of CyA (n = 18) or FK-506 (n = 24). We used Kolmogorov-Smirnov and subsequently Student t test, nonparametric Wilcoxon signed-rank test, and Mann-Whitney test for statistical analysis. Significance was achieved when P <or= 0.05. There was a statistically significant change in PTA results, occurring as decreased hearing perception, especially in high frequencies (4000, 6000, and 8000 Hz), in both ears of patients undergoing LT and receiving FK-506. Audiometric changes were not perceived pre- and posttransplantation in patients using CyA, except in the right ear, in the 3000-Hz range. In conclusion, LT patients presented worsening of hearing patterns after undergoing transplantation. The defect was significantly more accentuated in the high-frequency tones, particularly in individuals using FK-506 as the immunosuppressive regimen.
Maria Elena Fortes; Cláudio Augusto Marroni; Pedro Luis Coser; Carlos Abaeté de los Santos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society     Volume:  14     ISSN:  1527-6473     ISO Abbreviation:  Liver Transpl.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-03     Completed Date:  2008-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909185     Medline TA:  Liver Transpl     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-11     Citation Subset:  IM    
Copyright Information:
(c) 2008 AASLD.
Centro Universitário Metodista do Sul, Porto Alegre, RS, Brazil.
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MeSH Terms
Azathioprine / therapeutic use
Cyclosporine / therapeutic use*
Functional Laterality
Hearing / drug effects,  physiology*
Immunosuppressive Agents / therapeutic use*
Liver Transplantation / immunology,  physiology*
Middle Aged
Prednisone / therapeutic use
Retrospective Studies
Tacrolimus / therapeutic use
Reg. No./Substance:
0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 446-86-6/Azathioprine; 53-03-2/Prednisone; 59865-13-3/Cyclosporine

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