| Audiometric changes in patients undergoing liver transplantation using distinct immunosuppressive protocols. | |
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MedLine Citation:
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PMID: 18383080 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to disclose a possible association of hearing defects with the use of either cyclosporin (CyA) or tacrolimus (FK-506) in patients undergoing liver transplantation (LT). Pure-tone audiometry (PTA) was performed in the same 42 patients before and after LT. Audiometric frequencies recorded ranged from 250 to 8000 Hz. Patients were divided into 2 groups according to the use of CyA (n = 18) or FK-506 (n = 24). We used Kolmogorov-Smirnov and subsequently Student t test, nonparametric Wilcoxon signed-rank test, and Mann-Whitney test for statistical analysis. Significance was achieved when P <or= 0.05. There was a statistically significant change in PTA results, occurring as decreased hearing perception, especially in high frequencies (4000, 6000, and 8000 Hz), in both ears of patients undergoing LT and receiving FK-506. Audiometric changes were not perceived pre- and posttransplantation in patients using CyA, except in the right ear, in the 3000-Hz range. In conclusion, LT patients presented worsening of hearing patterns after undergoing transplantation. The defect was significantly more accentuated in the high-frequency tones, particularly in individuals using FK-506 as the immunosuppressive regimen. |
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Authors:
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Maria Elena Fortes; Cláudio Augusto Marroni; Pedro Luis Coser; Carlos Abaeté de los Santos |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society Volume: 14 ISSN: 1527-6473 ISO Abbreviation: Liver Transpl. Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-03 Completed Date: 2008-08-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100909185 Medline TA: Liver Transpl Country: United States |
Other Details:
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Languages: eng Pagination: 509-11 Citation Subset: IM |
Copyright Information:
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(c) 2008 AASLD. |
Affiliation:
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Centro Universitário Metodista do Sul, Porto Alegre, RS, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Audiometry Azathioprine / therapeutic use Cyclosporine / therapeutic use* Female Functional Laterality Hearing / drug effects, physiology* Humans Immunosuppressive Agents / therapeutic use* Liver Transplantation / immunology, physiology* Male Middle Aged Prednisone / therapeutic use Retrospective Studies Tacrolimus / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 446-86-6/Azathioprine; 53-03-2/Prednisone; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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