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Audiological and genetics studies in high-risk infants.
MedLine Citation:
PMID:  22183286     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Hearing is one of the main ways with which one person can contact the external world; it plays a key role in their integration with society. AIM: The objective of this study was to analyze the results of the hearing, medical and genetic evaluation of high-risk infants who failed the newborn hearing screening. MATERIALS AND METHODS: Clinical and experimental study. We assessed thirty-eight neonates, with ages between one and six months. The infants underwent the following procedures: medical interview; immittance testing; Brainstem Auditory Evoked Potential; Transient Evoked Otoacoustic Emission and otorhinolaryngological evaluation. DNA extraction from the oral mucosa was performed for genetic studies using the protocol method adapted from the Human Genetics Lab of the CBMEG/UNICAMP. RESULTS: Regarding gender and presence of risk factors, significant statistically differences were not found in normal hearing infants and in those with hearing loss. Concerning gestational age, term infants were more affected by hearing loss. Hearing loss was identified in 58% of the sample, conduction hearing loss represented 31.5% (12/38) and neurossensory 28.9% of cases. There were none of the genetic mutations most commonly seen in cases with a genetic etiology. CONCLUSION: Hearing loss was identified in the majority of High-risk infants.
Authors:
Maria Francisca Colella-Santos; Maria de Fátima de Campos Françozo; Christiane Marques do Couto; Maria Cecilia Marconi Pinheiro Lima; Tatiana Guilhermino Tazinazzio; Arthur Menino Castilho; Edi Lucia Sartorato
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Brazilian journal of otorhinolaryngology     Volume:  77     ISSN:  1808-8686     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101207337     Medline TA:  Braz J Otorhinolaryngol     Country:  -    
Other Details:
Languages:  ENG; POR     Pagination:  784-790     Citation Subset:  -    
Affiliation:
Curso de Fonoaudiologia, Faculdade de Ciências Médicas, Unicamp.
Vernacular Title:
Estudo audiológico e genético de lactentes de alto risco.
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