| Atypical vimentin expression in a feline salivary gland adenocarcinoma with widespread metastases. | |
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MedLine Citation:
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PMID: 20046042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report herein a feline salivary gland adenocarcinoma with widespread metastases to draining lymph nodes, liver and lung, as well as an unusual metastasis to the spleen. Histologically, the primary salivary gland tumor consisted of low columnar to polygonal epithelial cells forming tubules and trabeculae. The spleen was infiltrated with sheets of poorly differentiated large round cells. Interestingly, morphologic change in epithelial cells was accompanied with the acquisition of vimentin intermediate filaments, a feature particularly evident in the splenic metastasis. This study highlights the role of epithelial cell plasticity during carcinogenesis and metastasis. |
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Authors:
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Christelle Volmer; Yasmine Benal; Laura Caplier; Farasoa Rakotovao; Jean-Jacques Fontaine |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 71 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2010-01-04 Completed Date: 2010-02-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1681-4 Citation Subset: IM |
Affiliation:
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Ecole Nationale Vétérinaire d'Alfort, Marcy l'Etoile, France. c.volmer@hotmail.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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metabolism,
pathology,
veterinary* Animals Cat Diseases / metabolism*, pathology Cats Gene Expression Regulation, Neoplastic Liver Neoplasms / metabolism, secondary, veterinary Lung Neoplasms / metabolism, secondary, veterinary Male Salivary Gland Neoplasms / metabolism, pathology, veterinary* Splenic Neoplasms / metabolism, secondary, veterinary Vimentin / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Vimentin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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