Document Detail


Atypical vimentin expression in a feline salivary gland adenocarcinoma with widespread metastases.
MedLine Citation:
PMID:  20046042     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report herein a feline salivary gland adenocarcinoma with widespread metastases to draining lymph nodes, liver and lung, as well as an unusual metastasis to the spleen. Histologically, the primary salivary gland tumor consisted of low columnar to polygonal epithelial cells forming tubules and trabeculae. The spleen was infiltrated with sheets of poorly differentiated large round cells. Interestingly, morphologic change in epithelial cells was accompanied with the acquisition of vimentin intermediate filaments, a feature particularly evident in the splenic metastasis. This study highlights the role of epithelial cell plasticity during carcinogenesis and metastasis.
Authors:
Christelle Volmer; Yasmine Benal; Laura Caplier; Farasoa Rakotovao; Jean-Jacques Fontaine
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of veterinary medical science / the Japanese Society of Veterinary Science     Volume:  71     ISSN:  0916-7250     ISO Abbreviation:  J. Vet. Med. Sci.     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-04     Completed Date:  2010-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9105360     Medline TA:  J Vet Med Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  1681-4     Citation Subset:  IM    
Affiliation:
Ecole Nationale Vétérinaire d'Alfort, Marcy l'Etoile, France. c.volmer@hotmail.fr
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / metabolism,  pathology,  veterinary*
Animals
Cat Diseases / metabolism*,  pathology
Cats
Gene Expression Regulation, Neoplastic
Liver Neoplasms / metabolism,  secondary,  veterinary
Lung Neoplasms / metabolism,  secondary,  veterinary
Male
Salivary Gland Neoplasms / metabolism,  pathology,  veterinary*
Splenic Neoplasms / metabolism,  secondary,  veterinary
Vimentin / genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Vimentin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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