Document Detail

Atypical tumour-like involvement of the colon in secondary systemic amyloidosis which vanished after 1 month of observation.
MedLine Citation:
PMID:  22699464     Owner:  NLM     Status:  In-Data-Review    
Amyloidosis occurs as a result of the extracellular deposition of protein fibrils in organs and tissues, thus causing mild to severe pathophysiological changes. The gastrointestinal tract is a common site of amyloid deposition. While intestinal amyloidosis frequently results in polypoid lesions, ulcerations, nodules and petechial mucosal haemorrhage, tumour-like lesions are rarely developed and infrequently diagnosed before the resection because of the difficulty in differentiating them from colon cancer. The authors herein reported a case of intestinal amyloid A amyloidosis with a complication of a tumour-like lesion endoscopically resembling a malignant lesion, which was completely diminished after 1 month of observation with bowel rest. Such conservative treatment is a feasible option to cure intestinal tumour-like lesions in patients with intestinal amyloidosis when no neoplastic change is histologically detected, possibly decreasing the need for surgery of the fragile mucosa.
Katuyoshi Ando; Mikihiro Fujiya; Takahiro Ito; Ryuji Sugiyama; Toshie Nata; Yoshiki Nomura; Nobuhiro Ueno; Shin Kashima; Chisato Ishikawa; Yuhiei Inaba; Kentaro Moriichi; Kotaro Okamoto; Katsuya Ikuta; Yusuke Mizukami; Yoshihiko Tokusashi; Naoyuki Miyokawa; Jiro Watari; Yutaka Kohgo
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Publication Detail:
Type:  Journal Article     Date:  2011-03-24
Journal Detail:
Title:  BMJ case reports     Volume:  2011     ISSN:  1757-790X     ISO Abbreviation:  BMJ Case Rep     Publication Date:  2011  
Date Detail:
Created Date:  2012-06-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101526291     Medline TA:  BMJ Case Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical University, Asahikawa, Japan.
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