Document Detail

Atypical pyoderma gangrenosum in a patient with osteomyelofibrosis.
MedLine Citation:
PMID:  18050976     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Atypical forms of pyoderma gangrenosum generally appear on the upper extremities; most frequently they are associated with myeloproliferative disorders, including osteomyelofibrosis. A response to systemic steroids is more pronounced than in classical form. Sometimes it may be the first sign of an underlying malignancy. CASE REPORT: We reported a patient with atypical pyoderma gangrenosum developed during the course of a myeloid malignancy--osteomyelofibrosis. The lesions occurred after a minor trauma. Painful blistering plaques, with an elevated, bluish-gray border were located on the dorsal aspect of hands. No skin malignancy was found. The lesions resolved rapidly to systemic steroids. CONCLUSION: Considering the unusual clinical presentation which makes the diagnosis difficult, as well as the fact that atypical forms of pyoderma gangrenosum can be the first sign of malignancies, especially myeloproliferative ones, recognizing this entity enables timely guiding future investigations toward their prompt detection.
Dubravka Zivanović; Srdan Tanasilović; Dusan Skiljević; Maja Tomović; Andrija Bogdanović; Sonja Vesić; Ljiljana Medenica
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Vojnosanitetski pregled. Military-medical and pharmaceutical review     Volume:  64     ISSN:  0042-8450     ISO Abbreviation:  Vojnosanit Pregl     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-12-04     Completed Date:  2008-02-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  21530700R     Medline TA:  Vojnosanit Pregl     Country:  Serbia and Montenegro    
Other Details:
Languages:  eng     Pagination:  787-9     Citation Subset:  IM    
Clinical Center of Serbia, Institute of Dermatology and Venereology, Belgrad, Serbia.
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MeSH Terms
Hand Dermatoses / complications,  pathology
Primary Myelofibrosis / complications*
Pyoderma Gangrenosum / complications,  pathology*
Skin / parasitology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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