| Atypical presentation of Hodgkin's disease in a patient at risk for the acquired immunodeficiency syndrome. | |
| | |
MedLine Citation:
|
PMID: 3180129 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hodgkin's disease (HD) has been reported in association with the acquired immunodeficiency syndrome (AIDS) only occasionally, and these patients seemed to have aggressive unusual HD. We report an additional case of HD in a 50-year-old homosexual man with a marked change of his clinical course after the development of seropositivity to human immunodeficiency virus (HIV). In 1978, HD stage IIIA, nodular sclerosing type, was diagnosed and treated with splenectomy and total nodal radiotherapy, which led to a complete response lasting till 1985. The patient then reported to our clinic with generalized lymphadenopathy and paresis of the m. biceps and m. triceps due to an infiltration of C6/C7 by HD. Laboratory findings revealed a T4/T8 ratio of 0.5 and HIV antibodies. He was given chemotherapy (COPP), but after a good initial response he developed pulmonary infiltration of HD. Therapy was changed to ABVD, but the patient did not respond to treatment and died of progressive HD in 1986. We therefore conclude that the natural history of HD in patients at risk for AIDS may be altered to a higher malignant form, and treatment modalities used in these patients must be further evaluated. |
| | |
Authors:
|
H Keyserlingk; W D Ludwig; H Seibt; H Rühl; G Höffken |
Related Documents
:
|
14674669 - Molecular analysis of v(h)i+ b lymphocytes in hepatitis c patients. 12000489 - Large t-cell lymphoma in a 13-year-old girl with hyperimmunoglobulinemia e syndrome. 15161439 - Current treatment strategies for patients with hodgkin's lymphoma and hiv infection. 9255339 - Primary hepatic lymphoma associated with chronic hepatitis c. 19336959 - Cd20-negative cd138-positive leukemic large cell lymphoma with plasmablastic differenti... 9352239 - Viruses and cancers: possible role of hepatitis c virus. 11348949 - Risk factors for prophylaxis failure in patients receiving aerosol pentamidine for pneu... 14479499 - Histological changes in the thyroid in cirrhosis of the liver. 16308419 - Chronic hepatitis c in patients with hiv/aids: a new challenge in antiviral therapy. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Cancer detection and prevention Volume: 12 ISSN: 0361-090X ISO Abbreviation: Cancer Detect. Prev. Publication Date: 1988 |
Date Detail:
|
Created Date: 1988-12-16 Completed Date: 1988-12-16 Revised Date: 2006-04-24 |
Medline Journal Info:
|
Nlm Unique ID: 7704778 Medline TA: Cancer Detect Prev Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 243-8 Citation Subset: IM; X |
Affiliation:
|
Department of Hematology and Oncology, University Medical Center Steglitz, Free University of Berlin, West Berlin, Federal Republic of Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acquired Immunodeficiency Syndrome
/
complications* Adult Antineoplastic Combined Chemotherapy Protocols / therapeutic use Cyclophosphamide / administration & dosage HIV Seropositivity Hodgkin Disease / etiology, pathology* Humans Male Middle Aged Prednisone / administration & dosage Procarbazine / administration & dosage Risk Factors Vincristine / administration & dosage |
| Chemical | |
Reg. No./Substance:
|
0/COPP protocol; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine; 671-16-9/Procarbazine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Malignant lymphomas in patients with or at risk for AIDS: a report of 50 cases observed in Italy.
Next Document: Altered peripheral nerve conduction in HIV-patients.