Document Detail

Atypical neuroleptics and diabetes.
MedLine Citation:
PMID:  12909819     Owner:  NLM     Status:  MEDLINE    
Since a few years, an increasing number of cases of atypical neuroleptic-associated diabetes are reported in the literature. But few are dedicated to diabetologists. We report here two cases of patients with a severe deterioration of preexisting diabetes, with clozapine for the first case report and olanzapine for the second one. We also make a literature review and discuss the possible mechanisms involved in this atypical neuroleptic-associated diabetes. We recommend a thigh follow-up of weight, glycemic and lipidic parameters during psychotic patients treatment with atypical neuroleptics, in order to prevent or rapidly treat the metabolic complications described in the literature.
S Béliard; R Valero; B Vialettes
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Diabetes & metabolism     Volume:  29     ISSN:  1262-3636     ISO Abbreviation:  Diabetes Metab.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-08-11     Completed Date:  2004-01-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9607599     Medline TA:  Diabetes Metab     Country:  France    
Other Details:
Languages:  eng     Pagination:  296-9     Citation Subset:  IM    
Service de Nutrition, Maladies métaboliques, Endocrinologie, Hôpital de Sainte Marguerite, Marseille, France.
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MeSH Terms
Antipsychotic Agents / adverse effects*
Clozapine / adverse effects*
Diabetes Mellitus, Type 2 / chemically induced*
Disease Progression
Middle Aged
Pirenzepine / adverse effects*,  analogs & derivatives*
Reg. No./Substance:
0/Antipsychotic Agents; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine; 28797-61-7/Pirenzepine; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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