| Atypical mycobacteria in extrapulmonary disease among children. Incidence in Sweden from 1969 to 1990, related to changing BCG-vaccination coverage. | |
| | |
MedLine Citation:
|
PMID: 7579311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
SETTING: In April 1975, the general BCG vaccination of newborns in Sweden was replaced by selective vaccination of groups at increased risk of tuberculosis. OBJECTIVE: To relate the incidence of atypical mycobacterial disease in children to BCG vaccination. DESIGN: A nationwide survey in Sweden during the period 1969-90 disclosed 390 children under 15 years of age with bacteriologically confirmed atypical mycobacteria from extrapulmonary lesions. RESULTS: The average, annual incidence of atypical mycobacterial disease per 100,000 children under 5 years of age increased from 0.06 during the period 1969-74 to a maximum level of 5.7 during 1981-85. Among the cohorts born in Sweden in the period 1975-85, the cumulative incidence rate before 5 years of age was estimated at 26.8 per 100,000 non-BCG-vaccinated children and at 4.6 among those BCG-vaccinated, ratio 5.9 (95% confidence limits 1.6, 48.5). Mycobacterium avium-intracellulare was found in 83%. Disseminated, fatal disease developed in 3 children. The remaining ones suffered from local infections, most often lymph-node or soft-tissue lesions. The observed incidence of bacteriologically confirmed diagnosis was estimated to represent approximately 40% of the 'true' number, if patients with diagnosis based on histological, clinical and epidemiological findings only were included. CONCLUSION: The present study indicates that BCG vaccination plays a role in protection against localized disease caused by atypical mycobacteria in children. |
| | |
Authors:
|
V Romanus; H O Hallander; P Wåhlén; A M Olinder-Nielsen; P H Magnusson; I Juhlin |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Tubercle and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease Volume: 76 ISSN: 0962-8479 ISO Abbreviation: Tuber. Lung Dis. Publication Date: 1995 Aug |
Date Detail:
|
Created Date: 1995-12-01 Completed Date: 1995-12-01 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 9212467 Medline TA: Tuber Lung Dis Country: SCOTLAND |
Other Details:
|
Languages: eng Pagination: 300-10 Citation Subset: IM |
Affiliation:
|
Swedish Institute for Infectious Disease Control, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Age Distribution BCG Vaccine* Child Child, Preschool Female Humans Incidence Infant Infant, Newborn Male Mycobacterium Infections, Atypical / epidemiology*, prevention & control Mycobacterium avium-intracellulare Infection / epidemiology Prognosis Sex Distribution Sweden / epidemiology Vaccination |
| Chemical | |
Reg. No./Substance:
|
0/BCG Vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Value of bronchoalveolar lavage and gastric lavage in the diagnosis of pulmonary tuberculosis in chi...
Next Document: A controlled clinical trial of short-course chemotherapy for tuberculoma of the brain.