Document Detail

Atypical manifestations of reversible posterior leukoencephalopathy syndrome: findings on diffusion imaging and ADC mapping.
MedLine Citation:
PMID:  15536557     Owner:  NLM     Status:  MEDLINE    
Typically, reversible posterior leukoencephalopathy syndrome (RPLS) involves the parieto-occipital lobes. When regions of the brain other than the parieto-occipital lobes are predominantly involved, the syndrome can be called atypical RPLS. The purpose of this study is to find radiological and pathophysiological features of atypical RPLS by using diffusion-weighted imaging (D-WI). We retrospectively reviewed seven patients (two with eclampsia, one with cyclosporine neurotoxicity, and four with hypertensive encephalopathy) with atypical MR manifestations of RPLS. Changes in signal intensity on T2-weighted imaging (T2-WI) and D-WI, and ADC ratio, were analyzed. In patients with atypical manifestation of RPLS, high signal intensities on T2-WI were noted in the frontal lobe, basal ganglia, thalamus, brainstem, and subcortical white matter in regions other than the parieto-occipital lobes. These areas of increased signal intensities on T2-WI showed increased ADC values, representing vasogenic edema in all seven patients. This result should be very useful in differentiating atypical RPLS from other metabolic brain disorders that affect the same sites with cytotoxic edema.
K J Ahn; W J You; S L Jeong; J W Lee; B S Kim; J H Lee; D W Yang; Y M Son; S T Hahn
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Publication Detail:
Type:  Journal Article     Date:  2004-11-05
Journal Detail:
Title:  Neuroradiology     Volume:  46     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-09-27     Revised Date:  2006-01-27    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  978-83     Citation Subset:  IM    
Department of Radiology, College of Medicine, The Catholic University of Korea, St. Mary's Hospital, 62 Youido-Dong, Youngdeungpo-Gu, 150-713, Seoul, Korea.
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MeSH Terms
Brain / pathology*,  physiopathology*
Diffusion Magnetic Resonance Imaging
Mental Disorders / etiology,  pathology*,  physiopathology*
Remission, Spontaneous
Retrospective Studies
Risk Factors
Seizures / etiology,  pathology*,  physiopathology*
Comment In:
Neuroradiology. 2005 Sep;47(9):703-4; author reply 705   [PMID:  15951996 ]

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