Document Detail

Atypical lentiginous junctional naevi of the elderly and melanoma.
MedLine Citation:
PMID:  11982564     Owner:  NLM     Status:  MEDLINE    
The diagnosis of atypical lentiginous melanocytic naevi in chronic sun-damaged skin is a clinical and pathological challenge. Mottled skin in the elderly is a result of extensive freckling, guttate hypomelanosis, solar lentigines, seborrhoeic keratoses and small dark lentigines. In addition, atypical lentiginous junctional naevi may be seen as isolated lesions and may merge with lesions that are indistinguishable from lentigo maligna. The predominant site distribution of such lesions on the trunk and limbs and the presence of a nested naevoid pattern on biopsy differs from classical lentigo maligna, which develops mainly on the head and neck. Based on case studies combining dermatoscopy with clinical and pathological features, we have found that atypical lentiginous junctional naevi of the elderly may evolve to lentigo maligna and in some cases to small cell (naevoid) melanomas. Such lesions have been previously classified as dysplastic naevi, atypical melanocytic hyperplasia, atypical melanocytic proliferation, atypical lentiginous melanocytic proliferation or premalignant melanosis (McGovern). The current definition of lentigo maligna appears too narrow and the pathway to lentigo maligna in the elderly skin may include a naevoid subset.
Steven Kossard
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Publication Detail:
Type:  Addresses; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Australasian journal of dermatology     Volume:  43     ISSN:  0004-8380     ISO Abbreviation:  Australas. J. Dermatol.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-05-01     Completed Date:  2002-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0135232     Medline TA:  Australas J Dermatol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  93-101     Citation Subset:  IM    
Skin and Cancer Foundation Australia, 277 Bourke Street, Darlinghurst, Sydney, NSW 2010, Australia.
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MeSH Terms
Diagnosis, Differential
Hutchinson's Melanotic Freckle / diagnosis,  pathology*
Nevus / diagnosis,  pathology*
Nevus, Pigmented / diagnosis,  pathology*
Skin / pathology
Skin Aging
Skin Neoplasms / diagnosis,  pathology*

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