Document Detail


Atypical lateralization of ERP response to native and non-native speech in infants at risk for autism spectrum disorder.
MedLine Citation:
PMID:  23287023     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Language impairment is common in autism spectrum disorders (ASD) and is often accompanied by atypical neural lateralization. However, it is unclear when in development language impairment or atypical lateralization first emerges. To address these questions, we recorded event-related-potentials (ERPs) to native and non-native speech contrasts longitudinally in infants at risk for ASD (HRA) over the first year of life to determine whether atypical lateralization is present as an endophenotype early in development and whether these infants show delay in a very basic precursor of language acquisition: phonemic perceptual narrowing. ERP response for the HRA group to a non-native speech contrast revealed a trajectory of perceptual narrowing similar to a group of low-risk controls (LRC), suggesting that phonemic perceptual narrowing does not appear to be delayed in these high-risk infants. In contrast there were significant group differences in the development of lateralized ERP response to speech: between 6 and 12 months the LRC group displayed a lateralized response to the speech sounds, while the HRA group failed to display this pattern. We suggest the possibility that atypical lateralization to speech may be an ASD endophenotype over the first year of life.
Authors:
Anne M Seery; Vanessa Vogel-Farley; Helen Tager-Flusberg; Charles A Nelson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-12-06
Journal Detail:
Title:  Developmental cognitive neuroscience     Volume:  5     ISSN:  1878-9307     ISO Abbreviation:  Dev Cogn Neurosci     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-07     Completed Date:  2014-01-27     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  101541838     Medline TA:  Dev Cogn Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  10-24     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation / methods*
Child Development Disorders, Pervasive / diagnosis*,  physiopathology*
Cross-Sectional Studies
Endophenotypes
Evoked Potentials, Auditory / physiology*
Female
Follow-Up Studies
Functional Laterality / physiology*
Humans
Infant
Longitudinal Studies
Male
Risk Factors
Speech / physiology*
Grant Support
ID/Acronym/Agency:
AS7003//Autism Speaks; R01 DC 10290/DC/NIDCD NIH HHS; R01 DC010290/DC/NIDCD NIH HHS; R21 DC 08637/DC/NIDCD NIH HHS; R21 DC008637/DC/NIDCD NIH HHS
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