| Atypical language lateralisation associated with right fronto-temporal grey matter increases - a combined fMRI and VBM study in left-sided mesial temporal lobe epilepsy patients. | |
| | |
MedLine Citation:
|
PMID: 21839176 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
By combining language functional magnetic resonance imaging and voxel-based morphometry in patients with left-sided mesial temporal lobe epilepsy and hippocampal sclerosis, we studied whether atypical language dominance is associated with temporal and/or extratemporal cortical changes. Using verbal fluency functional magnetic resonance imaging for language lateralisation, we identified 20 patients with left-sided mesial temporal lobe epilepsy with hippocampal sclerosis and atypical language lateralisation. These patients were compared with a group of 20 matched left-sided mesial temporal lobe epilepsy patients who had typical language lateralisation. Using T1-weighted 3D images of all patients and voxel-based morphometry, we compared grey matter volumes between the groups of patients. We also correlated grey matter volumes with the degree of atypical language activation. Patients with atypical language lateralisation had increases of grey matter volumes, mainly within right-sided temporo-lateral cortex (x=59, y=-16, z=-1, T=6.36, p<.001 corrected), and less significantly within frontal brain regions compared to patients with typical language lateralisation. The degree of atypical fronto-temporal language activation (measured by lateralisation indices and relative functional magnetic resonance imaging activity) was correlated with right-sided temporal and frontal grey matter volumes. Patients with atypical language lateralisation did not differ in terms of language performance from patients with typical language dominance. Atypical language lateralisation in patients with left-sided mesial temporal lobe epilepsy was associated with increased grey matter volume within the non-epileptic right temporal and frontal lobe. Grey matter increases associated with atypical language might represent morphological changes underlying functional reorganisation of the language network. This hard-wired reorganised atypical language network seems to be suitable to support language functions. |
| | |
Authors:
|
Kirsten Labudda; Markus Mertens; Jozsef Janszky; Christian G Bien; Friedrich G Woermann |
Related Documents
:
|
19893706 - Tumor delineation: the weakest link in the search for accuracy in radiotherapy. 15337176 - Automated laser registration in image-guided surgery: evaluation of the correlation bet... 22170416 - Possible utility of mri using gd-eob-dtpa for estimating liver functional reserve. 21906896 - Enhancement pattern of small hepatocellular carcinoma (hcc) at contrast-enhanced us (ce... 22559646 - Dosimetric comparison of treatment plans based on free breathing, maximum, and average ... 6515506 - Mortality trends in the populations of the rsa from causes commonly observed in develop... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-8-2 |
Journal Detail:
|
Title: NeuroImage Volume: - ISSN: 1095-9572 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
|
Created Date: 2011-8-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9215515 Medline TA: Neuroimage Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
|
Mara Hospital, Bethel Epilepsy Center, Bielefeld, Germany; Department of Clinical Psychology and Psychotherapy, University of Bielefeld, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Form and motion make independent contributions to the response to biological motion in occipitotempo...
Next Document: A generalized regression model for region of interest analysis of fMRI data.