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Atypical hemolytic uremic syndrome in the Tunisian population.
MedLine Citation:
PMID:  20499172     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Hemolytic uremic syndrome consists of a triad of acquired hemolytic anemia, thrombocytopenia and renal failure.
AIM: Our objectives were to determine epidemiology, clinical and laboratory characteristics of patients with atypical hemolytic uremic syndrome (aHUS) to determine the relationship between the complement protein deficit and aHUS in the Tunisian population.
METHODS: We studied retrospectively four cases of atypical HUS in adults admitted in the Nephrology Department of Fattouma Bourguiba Universitary Hospital in Monastir between 2000 and 2008.
RESULTS: Three patients had renal failure that required dialysis. One of them received kidney transplantation with no further recurrence of aHUS. Three patients had normal C3, C4, CFH, and FB levels, and in all patients anti-FH autoantibodies were absent. The kidney biopsy of one patient showed in addition to lupus glomerulonephritis histological findings consistent with TMA. A decrease in C3, C4 and CFH levels in this patient was found both before and after the cure.
CONCLUSION: Nephrologists should be aware of autoimmune conditions and genetic abnormalities of the complement regulatory genes as possible pathogenic mechanisms in atypical HUS patients.
Authors:
Nadia Leban; Sabra Aloui; Dalel Touati; Ramzy Lakhdhar; Habib Skhiri; Gerard Lefranc; Abdellatif Achour; Mezri Elmay; Margarita Lopez-Trascasa; Pilar Sanchez-Corral; Jemni Chibani; Amel Haj Khelil
Publication Detail:
Type:  Journal Article     Date:  2010-05-25
Journal Detail:
Title:  International urology and nephrology     Volume:  43     ISSN:  1573-2584     ISO Abbreviation:  Int Urol Nephrol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0262521     Medline TA:  Int Urol Nephrol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  IM    
Affiliation:
Biochemistry and Molecular Biology Laboratory, Faculty of Pharmacy, AV. Avicenne, 5019, Monastir, Tunisia, lebannadia@yahoo.fr.
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