Document Detail

Atypical hearing loss in women with breast cancer receiving adjuvant treatment.
MedLine Citation:
PMID:  16135407     Owner:  NLM     Status:  MEDLINE    
There are no reports of adjuvant treatments for early breast cancer causing hearing loss. Yet in this exploratory study 14/16 women who had received Fluorouracil, Epirubicin and Cyclophosphamide (FEC) chemotherapy regimen, 11 of whom also received endocrine treatment, had reduced hearing sensitivity, with 9/16 being atypical. It is not clear whether this finding is related to oestrogen reduction and/or ototoxicity but a more detailed investigation in this area is warranted given the large number of women with breast cancer who receive adjuvant treatments.
V Jenkins; H Beveridge; R Low; S Mitra
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-30
Journal Detail:
Title:  Breast (Edinburgh, Scotland)     Volume:  15     ISSN:  0960-9776     ISO Abbreviation:  Breast     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-12     Completed Date:  2006-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9213011     Medline TA:  Breast     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  448-51     Citation Subset:  IM    
Cancer Research UK Psychosocial Oncology Group, Brighton and Sussex Medical School, University of Sussex, Falmer, East Sussex, and Department of Audiology, Royal Sussex County Hospital, Brighton, UK.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / adverse effects*
Audiometry, Pure-Tone
Breast Neoplasms / drug therapy*
Chemotherapy, Adjuvant
Hearing Loss / chemically induced*
Middle Aged
Pilot Projects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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