Document Detail

Atypical features in pleomorphic adenoma--a clinicopathologic study and implications for management.
MedLine Citation:
PMID:  16540285     Owner:  NLM     Status:  MEDLINE    
Pleomorphic adenoma is the most common salivary gland neoplasm and infrequently undergoes malignant transformation. Carcinoma ex pleomorphic adenoma is typically an infiltrative neoplasm with features of cellular pleomorphism, high mitotic activity, peri-neural and vascular invasion. More recently, sub-groups of pleomorphic adenoma have been described exhibiting vascular invasion and features of malignancy without evidence of extra-capsular extension. There is little information in the literature regarding how these different histological variants influence clinical presentation and outcome following primary treatment. Following a review of 100 consecutive pleomorphic adenomas removed from the major salivary glands, 4 cases with atypical histological features were found. Three tumours exhibited features of dysplasia/carcinoma without evidence of extra-capsular invasion and a further case demonstrated benign vascular invasion. There were no clinical features suggestive of the atypical nature of these neoplasms, though fine needle aspiration cytology (FNAC) was suspicious of a malignancy in 2 cases and CT scan in 1 case. Patients underwent a superficial parotidectomy or submandibular gland excision based on the location of the lesion. All lesions were completely excised and there were no recurrences in this series.
M Ethunandan; R Witton; G Hoffman; A Spedding; P A Brennan
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Publication Detail:
Type:  Journal Article     Date:  2006-03-15
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  35     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-19     Completed Date:  2006-08-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  608-12     Citation Subset:  D; IM    
Maxillofacial unit, Queen Alexandra Hospital, Portsmouth PO6 3LY, United Kingdom.
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MeSH Terms
Adenoma, Pleomorphic / pathology*
Middle Aged
Retrospective Studies
Salivary Gland Neoplasms / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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