| Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism. | |
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MedLine Citation:
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PMID: 19765688 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Previous studies have documented atypicalities in face/object processing in children and adults with autism spectrum disorders (ASDs). To investigate whether such atypicalities may reflect a genetically mediated risk factor present early in development, we measured face/object processing in 10-month-old high-risk infants who carry some of the genes associated with ASD because they have an older sibling diagnosed with the disorder. METHODS: We employed event-related potentials (ERPs) to measure cortical responses to pictures of faces and objects, the objects being toys. Latencies and amplitudes of four ERP components (P100, N290, P400, and Nc) were compared between 20 high-risk infants and 20 low-risk control subjects (infants with no family history of ASD). RESULTS: Responses to faces versus objects differed between high- and low-risk infants for the latencies of the N290 and P400. Differences were driven by faster responses to faces than objects in low-risk, but not high-risk, infants (P400) and, conversely, faster responses to objects than faces in high-risk, but not low-risk, infants (N290). Object responses were also faster in high-risk than low-risk infants (both N290 and P400). Left versus right hemisphere responses also differed between high- and low-risk infants for the amplitudes of the P100, N290, and P400; collapsed across faces/objects, low-risk, but not high-risk, infants exhibited hemisphere asymmetries. CONCLUSIONS: Genetic risk for ASD is associated with atypical face versus object processing and an atypical lack of hemispheric asymmetry early in life. These atypicalities might contribute to development of the disorder. |
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Authors:
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Joseph P McCleery; Natacha Akshoomoff; Karen R Dobkins; Leslie J Carver |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-09-18 |
Journal Detail:
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Title: Biological psychiatry Volume: 66 ISSN: 1873-2402 ISO Abbreviation: Biol. Psychiatry Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-30 Completed Date: 2010-01-06 Revised Date: 2013-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 950-7 Citation Subset: IM |
Affiliation:
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Department of Psychology, University of California, San Diego, La Jolla, California 92093-0109, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Autistic Disorder / pathology, physiopathology* Brain / physiopathology* Brain Mapping Cerebral Cortex / physiopathology Child Child, Preschool Electroencephalography / methods Evoked Potentials / physiology Face* Female Fourier Analysis Functional Laterality / physiology* Humans Infant Male Neuropsychological Tests Pattern Recognition, Visual / physiology* Photic Stimulation / methods Reaction Time / physiology Risk |
| Grant Support | |
ID/Acronym/Agency:
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AS1305//Autism Speaks; AS1695//Autism Speaks; K23MH071796/MH/NIMH NIH HHS; R01 HD052804-01A2/HD/NICHD NIH HHS; R01 HD052804-01A2/HD/NICHD NIH HHS; R01 HD052804-04/HD/NICHD NIH HHS; R21 HD043739/HD/NICHD NIH HHS |
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