Document Detail


Atypical face versus object processing and hemispheric asymmetries in 10-month-old infants at risk for autism.
MedLine Citation:
PMID:  19765688     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Previous studies have documented atypicalities in face/object processing in children and adults with autism spectrum disorders (ASDs). To investigate whether such atypicalities may reflect a genetically mediated risk factor present early in development, we measured face/object processing in 10-month-old high-risk infants who carry some of the genes associated with ASD because they have an older sibling diagnosed with the disorder.
METHODS: We employed event-related potentials (ERPs) to measure cortical responses to pictures of faces and objects, the objects being toys. Latencies and amplitudes of four ERP components (P100, N290, P400, and Nc) were compared between 20 high-risk infants and 20 low-risk control subjects (infants with no family history of ASD).
RESULTS: Responses to faces versus objects differed between high- and low-risk infants for the latencies of the N290 and P400. Differences were driven by faster responses to faces than objects in low-risk, but not high-risk, infants (P400) and, conversely, faster responses to objects than faces in high-risk, but not low-risk, infants (N290). Object responses were also faster in high-risk than low-risk infants (both N290 and P400). Left versus right hemisphere responses also differed between high- and low-risk infants for the amplitudes of the P100, N290, and P400; collapsed across faces/objects, low-risk, but not high-risk, infants exhibited hemisphere asymmetries.
CONCLUSIONS: Genetic risk for ASD is associated with atypical face versus object processing and an atypical lack of hemispheric asymmetry early in life. These atypicalities might contribute to development of the disorder.
Authors:
Joseph P McCleery; Natacha Akshoomoff; Karen R Dobkins; Leslie J Carver
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-09-18
Journal Detail:
Title:  Biological psychiatry     Volume:  66     ISSN:  1873-2402     ISO Abbreviation:  Biol. Psychiatry     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-06     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0213264     Medline TA:  Biol Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  950-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Autistic Disorder / pathology,  physiopathology*
Brain / physiopathology*
Brain Mapping
Cerebral Cortex / physiopathology
Child
Child, Preschool
Electroencephalography / methods
Evoked Potentials / physiology
Face*
Female
Fourier Analysis
Functional Laterality / physiology*
Humans
Infant
Male
Neuropsychological Tests
Pattern Recognition, Visual / physiology*
Photic Stimulation / methods
Reaction Time / physiology
Risk
Grant Support
ID/Acronym/Agency:
AS1305//Autism Speaks; AS1695//Autism Speaks; K23MH071796/MH/NIMH NIH HHS; R01 HD052804/HD/NICHD NIH HHS; R01 HD052804-01A2/HD/NICHD NIH HHS; R01 HD052804-01A2/HD/NICHD NIH HHS; R01 HD052804-04/HD/NICHD NIH HHS; R21 HD043739/HD/NICHD NIH HHS
Comments/Corrections

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