Document Detail

Atypical chronic myeloid leukaemia with trisomy 21 mosaicism as a sole chromosomal abnormality.
MedLine Citation:
PMID:  10953987     Owner:  NLM     Status:  MEDLINE    
We present a 46-year-old patient with Ph-chromosome negative, bcr-negative chronic myeloid leukaemia (CML) in accelerated phase with a clonal trisomy 21 in the leukaemic blast cells. A rapid progress of disease with appearance of monocytosis is described, showing similar features to chronic myelomonocytic leukaemia (CMML). Heterogeneous characteristics and possible distinction of these two entities are discussed.
D Benedek; M Kiehl; A Draube; J Chemnitz; V Diehl; D Söhngen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  38     ISSN:  1042-8194     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2001-01-23     Completed Date:  2001-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  639-44     Citation Subset:  IM    
First Department of Internal Medicine, University Hospital Köln, Germany.
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MeSH Terms
Chromosomes, Human, Pair 21*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / diagnosis,  genetics*,  pathology,  physiopathology
Middle Aged

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