Document Detail

Atypical biochemical findings in Turner's syndrome: identification of a possible subset.
MedLine Citation:
PMID:  6436075     Owner:  NLM     Status:  MEDLINE    
Two patients with Turner's syndrome, Hashimoto's thyroiditis, and partial intrasellar arachnoidocele (empty sella) are described. Both patients had low basal and LH-RH-stimulated gonadotropin release and moderately exaggerated TSH and PRL response to insulin-induced hypoglycemia and TRH. Such findings are typical of a disturbance of the hypothalamic-pituitary axis. In our patients, these findings could be due to the presence of the intrasellar arachnoidocele or might represent a loss of the central dopaminergic tone possibly as the consequence of an autoimmune process. It remains to be established whether the frequency of intrasellar arachnoidocele and Hashimoto's thyroiditis in patients with Turner's syndrome justifies classification of the condition of these patients as a distinct subtype.
L J Valenta; A N Elias; M Bocian
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fertility and sterility     Volume:  42     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-18     Completed Date:  1984-12-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  798-802     Citation Subset:  IM    
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MeSH Terms
Alopecia / complications
Empty Sella Syndrome / complications
Follicle Stimulating Hormone / secretion
Gonadotropin-Releasing Hormone / diagnostic use
Hypothalamo-Hypophyseal System / metabolism
Luteinizing Hormone / secretion
Prolactin / secretion
Thyroiditis, Autoimmune / complications
Thyrotropin / secretion
Thyrotropin-Releasing Hormone / diagnostic use
Turner Syndrome / complications,  genetics,  metabolism*
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone; 33515-09-2/Gonadotropin-Releasing Hormone; 9002-62-4/Prolactin; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone; 9002-71-5/Thyrotropin

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