| Atypical bare nuclei in liquid-based cervical cytology and their significance. | |
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MedLine Citation:
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PMID: 20014552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the potential significance of atypical bare nuclei in ThinPrep (TP) technique (Cytyc Corp., Boxborough, Massachusetts, U.S.A.), liquid-based cervical cytology and their possible association with certain epithelial abnormalities. STUDY DESIGN: Four thousand seven hundred thirty-six TP cervical smears were reviewed over a period of 13 months. Cases in which atypical bare nuclei were detected were selected and were further studied for the clinical, cytomorphologic and histologic features associated with each case. Cases with "typical" bland-looking, free nuclei were excluded. RESULTS: Ten cases were found to have atypical bare nuclei in the reviewed TP cervical smears. Nine were found to be associated with high grade squamous intraepithelial lesions (HSILs) and 6 were nonkeratinizing-type HSIL, 5 of which had endocervical involvement. None were associated with low grade squamous intraepithelial lesions (LSILs). One was associated with endometrial serous papillary carcinoma. CONCLUSION: In this study we tried to illustrate the significance of atypical bare nuclei in TP cervical smears. An association of atypical bare nuclei with HSIL, but not with LSIL, was observed. Attempts were made to explain this association and to suggest the potential management implications for TP cervical smears with such atypical bare nuclei. |
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Authors:
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Badr AbdullGaffar; Mohamed Osman Kamal; Manar Khalid; Ravirani Samuel; Rafeea AlGhufli |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta cytologica Volume: 53 ISSN: 0001-5547 ISO Abbreviation: Acta Cytol. Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-12-17 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370307 Medline TA: Acta Cytol Country: United States |
Other Details:
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Languages: eng Pagination: 637-43 Citation Subset: IM |
Affiliation:
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Cytology Unit, Histopathology Department, Dubai Hospital, Dubai, United Arab Emirates. badraah009@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Cell Nucleus / pathology* Cervical Intraepithelial Neoplasia / pathology Female Humans Middle Aged Vaginal Smears / methods* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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