Document Detail

Atypical antipsychotics and pituitary neoplasms in the WHO database.
MedLine Citation:
PMID:  17285098     Owner:  NLM     Status:  MEDLINE    
Amisulpride and risperidone are potent dopamine D2 receptor blocking atypical antipsychotics that can cause hyperprolactinemia. Preclinical evidence shows that chronic administration of antipsychotics can cause pituitary adenomas in female mice. To investigate the clinical relevance in this finding, reports of pituitary neoplasms in the WHO adverse drug reaction (ADR) database were reviewed. Amisulpride and risperidone [corrected] had among the highest Information Component (IC) scores for benign pituitary neoplasm; amisulpride (IC = 3.31, IC025 = 1.83, 5 reports) and risperidone (IC = 4.03, IC025 = 3.33, 19 reports), and not otherwise specified (NOS) pituitary neoplasm: amisulpride (IC = 2.69, IC025 = 0.70, 3 reports) and risperidone (IC = 4.49, IC025 = 3.86, 23 reports). We conclude that there is a need for prospective studies to confirm causality and suggest that clinicians, until then, would consider a pituitary adenoma in patients experiencing severe hyperprolactinemia or associated symptoms when receiving potent D2 antagonists [corrected]
P Murali Doraiswamy; Gisela Schott; Kristina Star; Ralph Edwards; Bruno Mueller-Oerlinghausen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology bulletin     Volume:  40     ISSN:  0048-5764     ISO Abbreviation:  Psychopharmacol Bull     Publication Date:  2007  
Date Detail:
Created Date:  2007-02-07     Completed Date:  2007-05-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0101123     Medline TA:  Psychopharmacol Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  74-6     Citation Subset:  IM    
Department of Psychiatry and the Department of Medicine at Duke University Medical Center, DUMC 3018, Durham, NC 27514, USA.
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MeSH Terms
Adenoma / chemically induced*,  epidemiology
Adverse Drug Reaction Reporting Systems
Antipsychotic Agents / adverse effects*,  therapeutic use
Pituitary Neoplasms / chemically induced*,  epidemiology
Risperidone / adverse effects*,  therapeutic use
Schizophrenia / drug therapy*,  epidemiology
Sulpiride / adverse effects,  analogs & derivatives*,  therapeutic use
World Health Organization
Reg. No./Substance:
0/Antipsychotic Agents; 106266-06-2/Risperidone; 15676-16-1/Sulpiride; 53583-79-2/sultopride
Erratum In:
Psychopharmacol Bull. 2007;40(2):5

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