| Atypical antipsychotics and pituitary neoplasms in the WHO database. | |
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MedLine Citation:
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PMID: 17285098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amisulpride and risperidone are potent dopamine D2 receptor blocking atypical antipsychotics that can cause hyperprolactinemia. Preclinical evidence shows that chronic administration of antipsychotics can cause pituitary adenomas in female mice. To investigate the clinical relevance in this finding, reports of pituitary neoplasms in the WHO adverse drug reaction (ADR) database were reviewed. Amisulpride and risperidone [corrected] had among the highest Information Component (IC) scores for benign pituitary neoplasm; amisulpride (IC = 3.31, IC025 = 1.83, 5 reports) and risperidone (IC = 4.03, IC025 = 3.33, 19 reports), and not otherwise specified (NOS) pituitary neoplasm: amisulpride (IC = 2.69, IC025 = 0.70, 3 reports) and risperidone (IC = 4.49, IC025 = 3.86, 23 reports). We conclude that there is a need for prospective studies to confirm causality and suggest that clinicians, until then, would consider a pituitary adenoma in patients experiencing severe hyperprolactinemia or associated symptoms when receiving potent D2 antagonists [corrected] |
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Authors:
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P Murali Doraiswamy; Gisela Schott; Kristina Star; Ralph Edwards; Bruno Mueller-Oerlinghausen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychopharmacology bulletin Volume: 40 ISSN: 0048-5764 ISO Abbreviation: Psychopharmacol Bull Publication Date: 2007 |
Date Detail:
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Created Date: 2007-02-07 Completed Date: 2007-05-02 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0101123 Medline TA: Psychopharmacol Bull Country: United States |
Other Details:
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Languages: eng Pagination: 74-6 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and the Department of Medicine at Duke University Medical Center, DUMC 3018, Durham, NC 27514, USA. dorai001@mc.duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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chemically induced*,
epidemiology Adult Adverse Drug Reaction Reporting Systems Antipsychotic Agents / adverse effects*, therapeutic use Causality Female Humans Male Pituitary Neoplasms / chemically induced*, epidemiology Risk Risperidone / adverse effects*, therapeutic use Schizophrenia / drug therapy*, epidemiology Sulpiride / adverse effects, analogs & derivatives*, therapeutic use World Health Organization |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 106266-06-2/Risperidone; 15676-16-1/Sulpiride; 53583-79-2/sultopride |
| Comments/Corrections | |
Erratum In:
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Psychopharmacol Bull. 2007;40(2):5 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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