Document Detail

Atypical antipsychotics in severe anorexia nervosa in children and adolescents--review and case reports.
MedLine Citation:
PMID:  18000964     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To review the literature on the use of atypical antipsychotics in anorexia nervosa of children and adolescents and to present three case reports on quetiapine treatment of this subgroup. METHOD: Review of the literature and case report. RESULTS: Several case reports and two small open-label trials, mainly in adults, observed beneficial effects of olanzapine on anorexic psychopathology. Only 16 case reports have been published on children and adolescents. Because of its lower propensity to induce weight gain quetiapine might be favourable with regard to patients' compliance. Our case reports revealed positive psychopathological effects and good tolerability of quetiapine in minors with severe anorexia nervosa. Careful titration and intense drug monitoring are recommended. DISCUSSION: In a small subset of patients with severe, treatment- resistant anorexia nervosa, extreme weight phobia, delusional body image disturbances or severe hyperactivity might be considered as indications for atypical antipsychotics. However, controlled studies are needed.
Claudia Mehler-Wex; Marcel Romanos; Julia Kirchheiner; Ulrike M E Schulze
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  European eating disorders review : the journal of the Eating Disorders Association     Volume:  16     ISSN:  1099-0968     ISO Abbreviation:  Eur Eat Disord Rev     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-25     Completed Date:  2008-03-13     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9436977     Medline TA:  Eur Eat Disord Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  100-8     Citation Subset:  IM    
Copyright Information:
(c) 2007 John Wiley & Sons, Ltd and Eating Disorders Association
Department of Child and Adolescent Psychiatry/Psychotherapy, University of Ulm, Steinhövelstr. 5, Ulm, Germany.
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MeSH Terms
Anorexia Nervosa / drug therapy*,  psychology
Antipsychotic Agents / therapeutic use*
Benzodiazepines / therapeutic use
Dibenzothiazepines / therapeutic use*
Risperidone / therapeutic use
Reg. No./Substance:
0/Antipsychotic Agents; 0/Dibenzothiazepines; 0/quetiapine; 106266-06-2/Risperidone; 12794-10-4/Benzodiazepines; 132539-06-1/olanzapine

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