Document Detail

Atypical antipsychotics and diabetic ketoacidosis: a review.
MedLine Citation:
PMID:  23344556     Owner:  NLM     Status:  Publisher    
RATIONALE: Atypical antipsychotics have been linked to weight gain and type 2 diabetes, but are also associated with diabetic ketoacidosis (DKA), which can occur more acutely and in the absence of weight gain. OBJECTIVES: Our aim was to review current case reports of DKA in the context of atypical antipsychotic treatment to better understand (a) the scope of the problem, (b) its relationship to different atypical agents, (c) risk factors, (d) long-term outcome, and (e) putative mechanisms of action. METHOD: Searches in PubMed/Medline, as well as the University of Toronto's Scholar Portal, were performed for all relevant articles/abstracts in English. RESULTS: Sixty reports, yielding 69 cases, affirm that DKA is a rare but serious risk with almost all atypical antipsychotics; however, liability seems to vary between agents, at least partially mirroring risk of weight gain. Mean age of onset was 36.9 years (range 12-80), with 68 % of cases occurring in males, and 41 % in individuals of African American or African Caribbean descent. Over one third of cases present with either no weight gain or weight loss, and 61 % of these require ongoing treatment for glycemic control. Death occurred in 7.25 % of cases. CONCLUSION: While the underlying mechanisms are not well understood, antipsychotic-related DKA can occur soon after treatment onset and in the absence of weight gain. Although rare, clinicians must remain vigilant given its acute onset and potential lethality.
Melanie D Guenette; Margaret Hahn; Tony A Cohn; Celine Teo; Gary J Remington
Related Documents :
22096686 - Platypnea orthodeoxia syndrome and bronchopleural fistula following right pneumonectomy...
8435126 - Upper airway obstruction--an unusual complication following a minor scalding injury.
22183446 - Trochanteroplasty to treat sequelae of septic arthritis of the hip in infancy. case ser...
20080356 - Chemical assault and skin/eye burns: two representative cases, report from the acid sur...
22248756 - Fetoscopic release of an amniotic band with risk of amputation: case report and review ...
6887386 - Complete deficiency of adenine phosphoribosyl transferase: report of a new family.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-24
Journal Detail:
Title:  Psychopharmacology     Volume:  -     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Institute of Medical Science, Faculty of Medicine, University of Toronto, Medical Sciences Building, 1 King's College Circle, Room 2374, Toronto, Ontario, Canada, M5S 1A8.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Varenicline and cytisine: two nicotinic acetylcholine receptor ligands reduce ethanol intake in Univ...
Next Document:  Nicotine derived from the electronic cigarette improves time-based prospective memory in abstinent s...