Document Detail

Atypical acute promyelocytic leukemia (M3 variant): description of two cases.
MedLine Citation:
PMID:  6794299     Owner:  NLM     Status:  MEDLINE    
A variant form of acute promyelocytic leukemia has been recently described, characterized by a particular morphological picture associated with severe disseminated intravascular coagulation, with hyperleukocytosis at onset in most cases, and often a rapidly fatal outcome. Reviewing our case series of the past 3 years, we have identified 2 cases which presented with this typical clinical and hematological picture, in which diagnoses have been made retrospectively. The possibility of diagnosing this variant at onset even only on the basis of cytomorphology is discussed as well as the advisability of studying a new therapeutic approach for cases of this type in a attempt to improve its otherwise very unfavorable prognosis.
A C Rajnoldi; M Ferrari; G Cambiaghi; G C Secchi; C Uderzo; G Masera
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta haematologica     Volume:  66     ISSN:  0001-5792     ISO Abbreviation:  Acta Haematol.     Publication Date:  1981  
Date Detail:
Created Date:  1981-12-21     Completed Date:  1981-12-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0141053     Medline TA:  Acta Haematol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
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MeSH Terms
Blood Cells / pathology
Bone Marrow / pathology
Disseminated Intravascular Coagulation / etiology
Leukemia, Myeloid, Acute / complications,  diagnosis,  pathology*

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