| Atypical Papanicolaou smear in pregnancy. | |
| | |
MedLine Citation:
|
PMID: 15962016 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Atypical glandular cells (AGC) in Papanicolaou (Pap) smears can be associated with premalignant and malignant cervical and endometrial lesions. AGC is difficult to diagnose in pregnancy due to confusion with normal cellular changes that accompany graviditas. While guidelines have been established for management of AGC cases in the non-pregnant patient, special considerations are required when this is discovered during a pregnancy. A routine Pap smear performed on a 29-year-old woman being seen for a history of infertility yielded AGC and a high-grade squamous intraepithelial lesion. The patient achieved pregnancy 1 month later. Satisfactory colposcopic exam was performed with cytobrush sampling of the endocervical canal, in addition to 2 exocervical biopsies at 11 weeks gestation. Positive diagnosis of endocervical adenocarcinoma in situ resulted in a risk-informed decision to proceed with a cold knife conization of the cervix. Final pathology showed complete resection of the lesion with negative margins and an additional area of squamous dysplasia (cervical intraepithelial neoplasia, grade II to III). Appropriate follow-up was recommended. AGC found upon Pap smear during a pregnancy can be associated with significant pathology for which an aggressive management approach is warranted. |
| | |
Authors:
|
Thomas P Connolly; A C Evans |
Related Documents
:
|
11316936 - Nonspecific aerobic vaginitis and pregnancy. 7758646 - Obstetrical prognosis for carbon dioxide laser conisation of the uterine cervix. 9170836 - Cervical prolapse complicating pregnancy. 19796726 - Relationships between mechanical properties and extracellular matrix constituents of th... 11316936 - Nonspecific aerobic vaginitis and pregnancy. 20188356 - Oocyte cryopreservation outcomes including pre-cryopreservation and post-thaw meiotic s... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Clinical medicine & research Volume: 3 ISSN: 1539-4182 ISO Abbreviation: Clin Med Res Publication Date: 2005 Feb |
Date Detail:
|
Created Date: 2005-10-03 Completed Date: 2005-11-23 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 101175887 Medline TA: Clin Med Res Country: United States |
Other Details:
|
Languages: eng Pagination: 13-8 Citation Subset: IM |
Affiliation:
|
Department of Obstetrics and Gynecology, Marshfield Clinic-Wausau Center, 2727 Plaza Drive, Wausau, WI 54401, USA. connolly.thomas@mashfieldclinic.org |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Biopsy Carcinoma in Situ / diagnosis*, surgery Cervical Intraepithelial Neoplasia / diagnosis Cervix Uteri / pathology* Female Humans Pregnancy Pregnancy Complications, Neoplastic / diagnosis, surgery Uterine Cervical Neoplasms / diagnosis*, surgery Vaginal Smears* |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Surveillance of above- and below-ground mosquito breeding habitats in a rural midwestern community: ...
Next Document: Self-measurement of blood pressure at home in the management of hypertension.